Effect and mechanism of gomisin D on the isoproterenol induced myocardial injury in H9C2 cells and mice.

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  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: [Newark, N.J.?] : Harwood Academic Publishers,
    • Subject Terms:
      Isoproterenol*/pharmacology ; Schisandra*/chemistry ; Oxidative Stress*/drug effects ; Apoptosis*/drug effects ; Polycyclic Compounds*; Animals ; Mice ; Molecular Structure ; Calcium/metabolism ; Male ; Reactive Oxygen Species/metabolism ; Lignans/pharmacology ; Lignans/chemistry ; Cardiotonic Agents/pharmacology ; Cell Line ; Myocytes, Cardiac/drug effects ; Cyclooctanes/pharmacology ; Cyclooctanes/chemistry
    • Abstract:
      We established myocardial injury models in vivo and in vitro to investigate the cardioprotective effect of gomisin D obtained from Schisandra chinensis . Gomisin D significantly inhibited isoproterenol-induced apoptosis and hypertrophy in H9C2 cells. Gomisin D decreased serum BNP, ANP, CK-MB, cTn-T levels and histopathological alterations, and inhibited myocardial hypertrophy in mice. In mechanisms research, gomisin D reversed ISO-induced accumulation of intracellular ROS and Ca 2+ . Gomisin D further improved mitochondrial energy metabolism disorders by regulating the TCA cycle. These results demonstrated that gomisin D had a significant effect on isoproterenol-induced myocardial injury by inhibiting oxidative stress, calcium overload and improving mitochondrial energy metabolism.
    • Contributed Indexing:
      Keywords: Gomisin D; isoproterenol; mitochondrial energy metabolism; myocardial hypertrophy; myocardial injury
    • Accession Number:
      L628TT009W (Isoproterenol)
      SY7Q814VUP (Calcium)
      X13A57600T (gomisin J)
      0 (Reactive Oxygen Species)
      0 (Lignans)
      0 (Cardiotonic Agents)
      0 (Cyclooctanes)
      0 (Polycyclic Compounds)
    • Publication Date:
      Date Created: 20240418 Date Completed: 20240503 Latest Revision: 20240503
    • Publication Date:
      20240503
    • Accession Number:
      10.1080/10286020.2024.2336152
    • Accession Number:
      38634612