Prmt7 is required for the osteogenic differentiation of mesenchymal stem cells via modulation of BMP signaling.

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  • Additional Information
    • Source:
      Publisher: Korean Society for Biochemistry and Molecular Biology Country of Publication: Korea (South) NLM ID: 101465334 Publication Model: Print Cited Medium: Internet ISSN: 1976-670X (Electronic) Linking ISSN: 19766696 NLM ISO Abbreviation: BMB Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: Seoul : Korean Society for Biochemistry and Molecular Biology
    • Subject Terms:
      Mesenchymal Stem Cells*/metabolism ; Mesenchymal Stem Cells*/cytology ; Protein-Arginine N-Methyltransferases*/metabolism ; Protein-Arginine N-Methyltransferases*/genetics ; Osteogenesis*/genetics ; Cell Differentiation* ; Signal Transduction* ; Bone Morphogenetic Proteins*/metabolism; Animals ; Mice ; Cell Line
    • Abstract:
      Arginine methylation, which is catalyzed by protein arginine methyltransferases (Prmts), is known to play a key role in various biological processes. However, the function of Prmts in osteogenic differentiation of mesenchymal stem cells (MSCs) has not been clearly understood. In the current study, we attempted to elucidate a positive role of Prmt7 in osteogenic differentiation. Prmt7-depleted C3H/10T1/2 cells or bone marrow mesenchymal stem cells (BMSCs) showed the attenuated expression of osteogenic specific genes and Alizarin red staining compared to the wild-type cells. Furthermore, we found that Prmt7 deficiency reduced the activation of bone morphogenetic protein (BMP) signaling cascade, which is essential for the regulation of cell fate commitment and osteogenesis. Taken together, our data indicate that Prmt7 plays important regulatory roles in osteogenic differentiation. [BMB Reports 2024; 57(7): 330-335].
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    • Accession Number:
      EC 2.1.1.319 (Protein-Arginine N-Methyltransferases)
      0 (Bone Morphogenetic Proteins)
      EC 2.1.1.319 (PRMT7 protein, mouse)
    • Publication Date:
      Date Created: 20240417 Date Completed: 20240730 Latest Revision: 20240917
    • Publication Date:
      20240917
    • Accession Number:
      PMC11289507
    • Accession Number:
      38627951