Risk of heavy metal(loid) compositions in fine particulate matter on acute cardiovascular mortality: a poisson analysis in Anyang, China.

Publisher: Springer Verlag Country of Publication: United States NLM ID: 0374716 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1254 (Electronic) Linking ISSN: 00207128 NLM ISO Abbreviation: Int J Biometeorol Subsets: MEDLINE

Publication: New York, NY : Springer Verlag
Original Publication: Leiden.

Particulate Matter*/analysis ; Particulate Matter*/adverse effects ; Metals, Heavy*/analysis ; Cardiovascular Diseases*/mortality ; Air Pollutants*/analysis ; Air Pollutants*/adverse effects; Humans ; China/epidemiology ; Male ; Female ; Middle Aged ; Aged ; Adult ; Poisson Distribution ; Arsenic/analysis ; Cross-Over Studies

Fine particulate matter (PM 2.5 ) is a risk factor of cardiovascular disease. Associations between PM 2.5 compositions and cardiovascular disease are a point of special interest but inconsistent. This study aimed to explore the cardiovascular effects of heavy metal(loid) compositions in PM 2.5 . Data for mortality, air pollutants and meteorological factors in Anyang, China from 2017 to 2021 were collected. Heavy metal(loid) in PM 2.5 were monitored and examined monthly. A Case-crossover design was applied to the estimated data set. The interquartile range increase in cadmium (Cd), antimony (Sb) and arsenic (As) at lag 1 was associated with increment of 8.1% (95% CI: 3.3, 13.2), 4.8% (95% CI: 0.2, 9.5) and 3.5% (95% CI: 1.1, 6.0) cardiovascular mortality. Selenium in lag 2 was inversely associated with cerebrovascular mortality (RR = 0.920 95% CI: 0.862, 0.983). Current-day exposure of aluminum was positively associated with mortality from ischemic heart disease (RR = 1.083 95% CI: 1.001, 1.172). Stratified analysis indicated sex, age and season modified the cardiovascular effects of As (P < 0.05). Our study reveals that heavy metal(loid) play key roles in adverse effects of PM 2.5 . Cd, Sb and As were significant risk factors of cardiovascular mortality. These findings have potential implications for accurate air pollutants control and management to improve public health benefits.
(© 2024. The Author(s) under exclusive licence to International Society of Biometeorology.)

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81972981 National Natural Science Foundation of China; ZD202205 the Open Research Fund of National Health Commission Key Laboratory of Birth Defects Prevention & Henan Key Laboratory of Population Defects Prevention

Keywords: Cardiovascular mortality; Case-crossover; Composition; Fine particulate matter; Heavy metal(loid); Lag effect

0 (Particulate Matter)
0 (Metals, Heavy)
0 (Air Pollutants)
N712M78A8G (Arsenic)

Date Created: 20240416 Date Completed: 20240725 Latest Revision: 20240725

20240726

10.1007/s00484-024-02665-x

38625430