[Pharmacokinetics of 11 active components of Psoraleae Fructus in normal and diabetic rats].

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE
    • Publication Information:
      Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo
      Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989-
    • Subject Terms:
      Drugs, Chinese Herbal*/pharmacokinetics ; Diabetes Mellitus, Type 2* ; Diabetes Mellitus, Experimental*/drug therapy ; Psoralea* ; Furocoumarins* ; Phenols*; Humans ; Rats ; Female ; Male ; Animals ; Tandem Mass Spectrometry/methods ; Flavonoids/pharmacology ; Ficusin ; Coumarins ; Monoterpenes
    • Abstract:
      A total of 11 active ingredients including psoralen, isopsoralen, bakuchiol, bavachalcone, bavachinin, corylin, coryfolin, isobavachalcone, neobavaisoflavone, bakuchalcone, and corylifol A from Psoraleae Fructus in the plasma samples of diabetic and normal rats were simultaneously determined by UHPLC-MS/MS. The pharmacokinetic parameters were calculated to elucidate the pharmacokinetic profiles of coumarins, flavonoids, and monoterpene phenols in normal and diabetic rats. The rat model of type 2 diabetes mellitus(T2DM) was induced by a high-sugar and high-fat diet combined with injection of 1% streptozotocin every two days. The plasma samples were collected at different time points after the rats were administrated with Psoraleae Fructus. The proteins in the plasma samples were precipitated by ethyl acetate, and the plasma concentrations of the 11 components of Psoraleae Fructus were determined by UHPLC-MS/MS. The pharmacokinetic parameters were calculated by DAS 3.0. The results showed that the pharmacokinetic beha-viors of 8 components including psoralen, isopsoralen, bakuchiol, and bavachinin from Psoraleae Fructus in both female and male mo-del rats were significantly different from those in normal rats. Among them, the coumarins including psoralen, isopsoralen, and corylin showed lowered levels in the blood of both female and male model rats. The flavonoids(bavachinin, corylifol A, and bakuchalcone) and the monoterpene phenol bakuchiol showed decreased levels in the female model rats but elevated levels in the male model rats. It is suggested that the dosage of Psoraleae Fructus should be reasonably adjusted for the patients of different genders at the time of clinical administration.
    • Contributed Indexing:
      Keywords: Psoraleae Fructus; UHPLC-MS/MS; diabetes; pharmacokinetics
    • Accession Number:
      OT12HJU3AR (bakuchiol)
      0 (Drugs, Chinese Herbal)
      0 (Furocoumarins)
      0 (Flavonoids)
      KTZ7ZCN2EX (Ficusin)
      0 (Coumarins)
      0 (Monoterpenes)
      0 (Phenols)
    • Publication Date:
      Date Created: 20240415 Date Completed: 20240417 Latest Revision: 20240417
    • Publication Date:
      20240417
    • Accession Number:
      10.19540/j.cnki.cjcmm.20231207.201
    • Accession Number:
      38621985