Molybdenum disulfide nanosheets promote the plasmid-mediated conjugative transfer of antibiotic resistance genes.

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  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: England NLM ID: 0401664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8630 (Electronic) Linking ISSN: 03014797 NLM ISO Abbreviation: J Environ Manage Subsets: MEDLINE
    • Publication Information:
      Original Publication: London ; New York, Academic Press.
    • Subject Terms:
      Molybdenum*/chemistry ; Plasmids*/genetics ; Disulfides*/chemistry ; Escherichia coli*/genetics ; Escherichia coli*/drug effects ; Drug Resistance, Microbial*/genetics; Conjugation, Genetic ; Anti-Bacterial Agents/pharmacology ; Gene Transfer, Horizontal
    • Abstract:
      The environmental safety of nanoscale molybdenum disulfide (MoS 2 ) has attracted considerable attention, but its influence on the horizontal migration of antibiotic resistance genes and the ecological risks entailed have not been reported. This study addressed the influence of exposure to MoS 2 at different concentrations up to 100 mg/L on the conjugative transfer of antibiotic resistance genes carried by RP4 plasmids with two strains of Escherichia coli. As a result, MoS 2 facilitated RP4 plasmid-mediated conjugative transfer in a dose-dependent manner. The conjugation of RP4 plasmids was enhanced as much as 7-fold. The promoting effect is mainly attributable to increased membrane permeability, oxidative stress induced by reactive oxygen species, changes in extracellular polymer secretion and differential expression of the genes involved in horizontal gene transfer. The data highlight the distinct dose dependence of the conjugative transfer of antibiotic resistance genes and the need to improve awareness of the ecological and health risks of nanoscale transition metal dichalcogenides.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Antibiotic resistance genes; Conjugative transfer; Environmental risks; Molybdenum disulfide; Oxidative stress response
    • Accession Number:
      81AH48963U (Molybdenum)
      0 (Disulfides)
      ZC8B4P503V (molybdenum disulfide)
      0 (Anti-Bacterial Agents)
    • Publication Date:
      Date Created: 20240412 Date Completed: 20240503 Latest Revision: 20240503
    • Publication Date:
      20250114
    • Accession Number:
      10.1016/j.jenvman.2024.120827
    • Accession Number:
      38608575