Topical erythropoietin for the management of scleral necrosis after ocular chemical burns.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8913178 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1409 (Electronic) Linking ISSN: 03054179 NLM ISO Abbreviation: Burns Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1989-
    • Subject Terms:
      Burns, Chemical*/drug therapy ; Burns, Chemical*/therapy ; Erythropoietin*/therapeutic use ; Erythropoietin*/administration & dosage ; Necrosis* ; Sclera*/pathology ; Eye Burns*/chemically induced ; Eye Burns*/drug therapy ; Eye Burns*/therapy ; Eye Burns*/pathology; Humans ; Male ; Female ; Adult ; Middle Aged ; Prospective Studies ; Retrospective Studies ; Young Adult ; Administration, Topical ; Re-Epithelialization/drug effects ; Aged ; Adolescent ; Wound Healing/drug effects ; Treatment Outcome
    • Abstract:
      Purpose: To evaluate the efficacy of topical erythropoietin for chemical burn induced scleral necrosis.
      Methods: This study included 18 eyes of 16 patients with chemical burn induced scleral necrosis who presented within 6 weeks of the injury. In the prospective arm, 11 eyes received topical erythropoietin, 3000 IU/mL every 6 h, along with standard medical treatment. Retrospectively, we included 7 consecutive eyes of 7 patients who were managed with conventional treatment as historical control group. The main outcome measure was healing of avascular scleral lesions. The secondary outcome measure was complete re-epithelization of cornea.
      Results: Mean patient age was 39.8 ± 16.2 years in the erythropoietin group, and they presented 16.6 ± 15.2 days after acute chemical injury. Scleral necrosis improved in all eyes after 30.7 ± 23.2 days of treatment with topical erythropoietin. Corneal epithelial defects were completely healed in 10 eyes 61.9 ± 50.7 days after the start of the medication. In comparison, standard medical treatment alone did not improve scleral necrosis in the historical control group, necessitating ocular surface reconstruction including conjunctival advancement (1 eye) and tenonplasty (6 eyes).
      Conclusion: The results of our study showed that topical erythropoietin was effective in the management of chemical burn induced scleral necrosis. This treatment could avoid ocular surface reconstruction procedures in inflamed eyes.
      Competing Interests: Declaration of Competing Interest The authors do not have competing interests to declare.
      (Copyright © 2024 Elsevier Ltd and International Society of Burns Injuries. All rights reserved.)
    • Contributed Indexing:
      Keywords: Acute chemical burn; Scleral necrosis; Tenonplasty; Topical erythropoietin
    • Accession Number:
      11096-26-7 (Erythropoietin)
    • Publication Date:
      Date Created: 20240411 Date Completed: 20240612 Latest Revision: 20240715
    • Publication Date:
      20240715
    • Accession Number:
      10.1016/j.burns.2024.03.033
    • Accession Number:
      38604821