Genetic Subtypes of Prediabetes, Healthy Lifestyle, and Risk of Type 2 Diabetes.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
    • Publication Information:
      Publication: Alexandria, VA : American Diabetes Association
      Original Publication: [New York, American Diabetes Association]
    • Subject Terms:
      Diabetes Mellitus, Type 2*/genetics ; Diabetes Mellitus, Type 2*/epidemiology ; Prediabetic State*/genetics ; Prediabetic State*/epidemiology ; Healthy Lifestyle*; Humans ; Female ; Male ; Middle Aged ; Adult ; Hispanic or Latino/genetics ; Risk Factors ; Genetic Predisposition to Disease ; Aged ; White People/genetics ; United States/epidemiology
    • Abstract:
      Prediabetes is a heterogenous metabolic state with various risks for development of type 2 diabetes (T2D). In this study, we used genetic data on 7,227 US Hispanic/Latino participants without diabetes from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and 400,149 non-Hispanic White participants without diabetes from the UK Biobank (UKBB) to calculate five partitioned polygenetic risk scores (pPRSs) representing various pathways related to T2D. Consensus clustering was performed in participants with prediabetes in HCHS/SOL (n = 3,677) and UKBB (n = 16,284) separately based on these pPRSs. Six clusters of individuals with prediabetes with distinctive patterns of pPRSs and corresponding metabolic traits were identified in the HCHS/SOL, five of which were confirmed in the UKBB. Although baseline glycemic traits were similar across clusters, individuals in cluster 5 and cluster 6 showed an elevated risk of T2D during follow-up compared with cluster 1 (risk ratios [RRs] 1.29 [95% CI 1.08, 1.53] and 1.34 [1.13, 1.60], respectively). Inverse associations between a healthy lifestyle score and risk of T2D were observed across different clusters, with a suggestively stronger association observed in cluster 5 compared with cluster 1. Among individuals with a healthy lifestyle, those in cluster 5 had a similar risk of T2D compared with those in cluster 1 (RR 1.03 [0.91, 1.18]). This study identified genetic subtypes of prediabetes that differed in risk of progression to T2D and in benefits from a healthy lifestyle.
      (© 2024 by the American Diabetes Association.)
    • References:
      Ann Epidemiol. 2010 Aug;20(8):642-9. (PMID: 20609344)
      HGG Adv. 2021 Apr 8;2(2):. (PMID: 34604815)
      Diabetes Care. 2021 Jan;44(Suppl 1):S15-S33. (PMID: 33298413)
      Lancet Diabetes Endocrinol. 2019 Sep;7(9):684-694. (PMID: 31345776)
      Diabetes. 2014 Dec;63(12):4369-77. (PMID: 25048195)
      Am J Hum Genet. 2016 Jan 7;98(1):165-84. (PMID: 26748518)
      Nature. 2018 Oct;562(7726):203-209. (PMID: 30305743)
      Lancet Diabetes Endocrinol. 2018 May;6(5):361-369. (PMID: 29503172)
      Ann Epidemiol. 2010 Aug;20(8):629-41. (PMID: 20609343)
      PLoS Med. 2018 Sep 21;15(9):e1002654. (PMID: 30240442)
      Acta Diabetol. 2014 Aug;51(4):617-23. (PMID: 24532116)
      Bioinformatics. 2010 Jun 15;26(12):1572-3. (PMID: 20427518)
      Lancet Diabetes Endocrinol. 2016 Sep;4(9):789-798. (PMID: 27185609)
      Lancet. 2009 Nov 14;374(9702):1677-86. (PMID: 19878986)
      BMJ Open Diabetes Res Care. 2020 May;8(1):. (PMID: 32423965)
      N Engl J Med. 2001 Sep 13;345(11):790-7. (PMID: 11556298)
      Clin Diabetes Endocrinol. 2019 May 9;5:5. (PMID: 31086677)
      Nat Med. 2021 Jan;27(1):49-57. (PMID: 33398163)
      PLoS Med. 2015 Mar 31;12(3):e1001779. (PMID: 25826379)
      N Engl J Med. 2002 Feb 7;346(6):393-403. (PMID: 11832527)
      PLoS One. 2016 Sep 15;11(9):e0162388. (PMID: 27631769)
    • Grant Information:
      R01ES030994 United States ES NIEHS NIH HHS; R01 DK119268 United States DK NIDDK NIH HHS; N01HC65236 United States HL NHLBI NIH HHS; N01HC65235 United States HL NHLBI NIH HHS; N01HC65234 United States HL NHLBI NIH HHS; R01 HL105756 United States HL NHLBI NIH HHS; N01HC65237 United States HL NHLBI NIH HHS; R01 HL140976 United States HL NHLBI NIH HHS; R01DK119268 United States DK NIDDK NIH HHS; R01 HL136266 United States HL NHLBI NIH HHS; R01 ES030994 United States ES NIEHS NIH HHS; R01 DK120870 United States DK NIDDK NIH HHS; P30 DK063491 United States DK NIDDK NIH HHS; P30 DK111022 United States DK NIDDK NIH HHS; N01HC65233 United States HL NHLBI NIH HHS; R01 HL060712 United States HL NHLBI NIH HHS; UM1 DK078616 United States DK NIDDK NIH HHS
    • Publication Date:
      Date Created: 20240411 Date Completed: 20240620 Latest Revision: 20240623
    • Publication Date:
      20240623
    • Accession Number:
      PMC11189833
    • Accession Number:
      10.2337/db23-0699
    • Accession Number:
      38602922