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Genetic Subtypes of Prediabetes, Healthy Lifestyle, and Risk of Type 2 Diabetes.
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- Author(s): Li Y;Li Y; Chen GC; Chen GC; Moon JY; Moon JY; Arthur R; Arthur R; Sotres-Alvarez D; Sotres-Alvarez D; Daviglus ML; Daviglus ML; Pirzada A; Pirzada A; Mattei J; Mattei J; Perreira KM; Perreira KM; Rotter JI; Rotter JI; Taylor KD; Taylor KD; Chen YI; Chen YI; Wassertheil-Smoller S; Wassertheil-Smoller S; Wang T; Wang T; Rohan TE; Rohan TE; Kaufman JD; Kaufman JD; Kaplan R; Kaplan R; Qi Q; Qi Q
- Source:
Diabetes [Diabetes] 2024 Jul 01; Vol. 73 (7), pp. 1178-1187.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
- Publication Information: Publication: Alexandria, VA : American Diabetes Association
Original Publication: [New York, American Diabetes Association] - Subject Terms: Diabetes Mellitus, Type 2*/genetics ; Diabetes Mellitus, Type 2*/epidemiology ; Prediabetic State*/genetics ; Prediabetic State*/epidemiology ; Healthy Lifestyle*; Humans ; Female ; Male ; Middle Aged ; Adult ; Hispanic or Latino/genetics ; Risk Factors ; Genetic Predisposition to Disease ; Aged ; White People/genetics ; United States/epidemiology
- Abstract: Prediabetes is a heterogenous metabolic state with various risks for development of type 2 diabetes (T2D). In this study, we used genetic data on 7,227 US Hispanic/Latino participants without diabetes from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and 400,149 non-Hispanic White participants without diabetes from the UK Biobank (UKBB) to calculate five partitioned polygenetic risk scores (pPRSs) representing various pathways related to T2D. Consensus clustering was performed in participants with prediabetes in HCHS/SOL (n = 3,677) and UKBB (n = 16,284) separately based on these pPRSs. Six clusters of individuals with prediabetes with distinctive patterns of pPRSs and corresponding metabolic traits were identified in the HCHS/SOL, five of which were confirmed in the UKBB. Although baseline glycemic traits were similar across clusters, individuals in cluster 5 and cluster 6 showed an elevated risk of T2D during follow-up compared with cluster 1 (risk ratios [RRs] 1.29 [95% CI 1.08, 1.53] and 1.34 [1.13, 1.60], respectively). Inverse associations between a healthy lifestyle score and risk of T2D were observed across different clusters, with a suggestively stronger association observed in cluster 5 compared with cluster 1. Among individuals with a healthy lifestyle, those in cluster 5 had a similar risk of T2D compared with those in cluster 1 (RR 1.03 [0.91, 1.18]). This study identified genetic subtypes of prediabetes that differed in risk of progression to T2D and in benefits from a healthy lifestyle.
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PLoS One. 2016 Sep 15;11(9):e0162388. (PMID: 27631769) - Grant Information: R01ES030994 United States ES NIEHS NIH HHS; R01 DK119268 United States DK NIDDK NIH HHS; N01HC65236 United States HL NHLBI NIH HHS; N01HC65235 United States HL NHLBI NIH HHS; N01HC65234 United States HL NHLBI NIH HHS; R01 HL105756 United States HL NHLBI NIH HHS; N01HC65237 United States HL NHLBI NIH HHS; R01 HL140976 United States HL NHLBI NIH HHS; R01DK119268 United States DK NIDDK NIH HHS; R01 HL136266 United States HL NHLBI NIH HHS; R01 ES030994 United States ES NIEHS NIH HHS; R01 DK120870 United States DK NIDDK NIH HHS; P30 DK063491 United States DK NIDDK NIH HHS; P30 DK111022 United States DK NIDDK NIH HHS; N01HC65233 United States HL NHLBI NIH HHS; R01 HL060712 United States HL NHLBI NIH HHS; UM1 DK078616 United States DK NIDDK NIH HHS
- Publication Date: Date Created: 20240411 Date Completed: 20240620 Latest Revision: 20240623
- Publication Date: 20240623
- Accession Number: PMC11189833
- Accession Number: 10.2337/db23-0699
- Accession Number: 38602922
- Source:
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