[Research progress on the establishment and application of the hypoxia cell model in varicocele-associated male infertility].

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  • Author(s): Liang SL;Liang SL; Han L; Han L; Yuan SY; Yuan SY; Yuan SY
  • Source:
    Zhonghua nan ke xue = National journal of andrology [Zhonghua Nan Ke Xue] 2023 May; Vol. 29 (5), pp. 445-449.
  • Publication Type:
    Review; English Abstract; Journal Article
  • Language:
    Chinese
  • Additional Information
    • Source:
      Publisher: Nanjing Jun Qu Nanjing Zong Yi Yuan zhu ban, Zhonghua Nan Ke Xue Za Zhi Bian Ji Bu bian ji chu ban Country of Publication: China NLM ID: 101093592 Publication Model: Print Cited Medium: Internet ISSN: 1009-3591 (Print) Linking ISSN: 10093591 NLM ISO Abbreviation: Zhonghua Nan Ke Xue Subsets: MEDLINE
    • Publication Information:
      Original Publication: Nanjing : Nanjing Jun Qu Nanjing Zong Yi Yuan zhu ban, Zhonghua Nan Ke Xue Za Zhi Bian Ji Bu bian ji chu ban,
    • Subject Terms:
      Varicocele*/complications ; Infertility, Male*/etiology; Male ; Humans ; Hypoxia/complications ; Cell Hypoxia ; Cell Line
    • Abstract:
      Varicocele (VC) is considered as one of the primary causes of male infertility, and the pathogenesis and treatment measures for VC-associated male infertility (VMI) are being explored continuously. The construction of an appropriate in vitro model for VMI is of significant importance for the study of this disease. And the model of testis cell hypoxia, with its relatively stable experimental conditions, short cycle, good repeatability and few influencing factors, has been primarily applied in cellular experimental researches on VMI. This article reviews the selection of cell lines, use of modeling methods, and evaluation of cell models in recent VMI-related cellular experiments, aiming to provide some reference for scholars in their studies of the pathogenesis and treatment of VMI using the in vitro experimental model.
    • Contributed Indexing:
      Keywords: varicocele; infertility; hypoxia; cell model; testicular cell
    • Publication Date:
      Date Created: 20240411 Date Completed: 20240412 Latest Revision: 20240424
    • Publication Date:
      20240424
    • Accession Number:
      38602763