Iron‑sulfur clusters in viral proteins: Exploring their elusive nature, roles and new avenues for targeting infections.

Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2596 (Electronic) Linking ISSN: 01674889 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Res Subsets: MEDLINE

Original Publication: Amsterdam : Elsevier

Iron-Sulfur Proteins*/metabolism ; Iron-Sulfur Proteins*/genetics ; Virus Replication* ; Viral Proteins*/metabolism ; Viral Proteins*/genetics; Humans ; Viruses/metabolism ; Viruses/genetics ; Virus Diseases/metabolism ; Virus Diseases/virology ; Iron/metabolism ; Animals ; Host-Pathogen Interactions

Viruses have evolved complex mechanisms to exploit host factors for replication and assembly. In response, host cells have developed strategies to block viruses, engaging in a continuous co-evolutionary battle. This dynamic interaction often revolves around the competition for essential resources necessary for both host cell and virus replication. Notably, iron, required for the biosynthesis of several cofactors, including iron‑sulfur (FeS) clusters, represents a critical element in the ongoing competition for resources between infectious agents and host. Although several recent studies have identified FeS cofactors at the core of virus replication machineries, our understanding of their specific roles and the cellular processes responsible for their incorporation into viral proteins remains limited. This review aims to consolidate our current knowledge of viral components that have been characterized as FeS proteins and elucidate how viruses harness these versatile cofactors to their benefit. Its objective is also to propose that viruses may depend on incorporation of FeS cofactors more extensively than is currently known. This has the potential to revolutionize our understanding of viral replication, thereby carrying significant implications for the development of strategies to target infections.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Published by Elsevier B.V.)

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Z99 HD999999 United States ImNIH Intramural NIH HHS

Keywords: CIAO1; COVID-19; Cytoplasmic iron‑sulfur cluster assembly complex; FAM96B; HSC20 (aka HSCB) cochaperone; HSPA9 chaperone; Iron‑sulfur cluster assembly; MMS19; SARS-CoV-2; Viral proteins; Viral replication

0 (Iron-Sulfur Proteins)
0 (Viral Proteins)
E1UOL152H7 (Iron)

Date Created: 20240410 Date Completed: 20240529 Latest Revision: 20240601

20240601

PMC11139609

10.1016/j.bbamcr.2024.119723

38599324