Noninvasive Techniques for Tracking Biological Aging of the Cardiovascular System: JACC Family Series.

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    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 101467978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7591 (Electronic) Linking ISSN: 18767591 NLM ISO Abbreviation: JACC Cardiovasc Imaging Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York : Elsevier
    • Subject Terms:
    • Abstract:
      Population aging is one of the most important demographic transformations of our time. Increasing the "health span"-the proportion of life spent in good health-is a global priority. Biological aging comprises molecular and cellular modifications over many years, which culminate in gradual physiological decline across multiple organ systems and predispose to age-related illnesses. Cardiovascular disease is a major cause of ill health and premature death in older people. The rate at which biological aging occurs varies across individuals of the same age and is influenced by a wide range of genetic and environmental exposures. The authors review the hallmarks of biological cardiovascular aging and their capture using imaging and other noninvasive techniques and examine how this information may be used to understand aging trajectories, with the aim of guiding individual- and population-level interventions to promote healthy aging.
      Competing Interests: Funding Support and Author Disclosures Dr Raisi-Estabragh recognizes the National Institute for Health and Care Research Integrated Academic Training Programme, which supports her academic clinical lectureship post. Dr Szabo has received support from the Barts Charity (G-002389). Dr Schuermans has received support from the Belgian American Educational Foundation. Dr Vágó was supported by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund (Project no. TKP2021-NKTA- 46). Dr Ng was supported by the British Heart Foundation. Dr Pavanello has received support of “PE8 Ageing Well in an Ageing Society—AGE-IT,” funded by the European Union—Next Generation EU–NRRP M6C2—Investment 2.1 Enhancement and Strengthening of Biomedical Research in the NHS. Dr Marwick has received funding by an investigator grant (2008129) from the National Health and Medical Research Council of Australia. Dr Petersen acknowledges the SmartHeart Engineering and Physical Sciences Research Council program grant (EP/P001009/1); and provides consultancy to Cardiovascular Imaging. Drs Petersen and Szabo have received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement 825903 (euCanSHare project). The authors acknowledge the support of the National Institute for Health and Care Research Barts Biomedical Research Centre (NIHR203330), a delivery partnership of Barts Health NHS Trust, Queen Mary University of London, St. George’s University Hospitals NHS Foundation Trust, and St. George’s University of London. Drs Salih and Petersen acknowledge support from the Barts Charity (G-002523) and the British Heart Foundation (PG/21/10619). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
      (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: biological heart age; cardiac computed tomography; cardiac magnetic resonance; echocardiography; healthy aging; molecular markers; multimodality cardiovascular imaging
    • Publication Date:
      Date Created: 20240410 Date Completed: 20240508 Latest Revision: 20240508
    • Publication Date:
      20240509
    • Accession Number:
      10.1016/j.jcmg.2024.03.001
    • Accession Number:
      38597854