The combined exposure of polystyrene microplastics and high-fat feeding affects the intestinal pathology damage and microbiome in zebrafish.

Publisher: Blackwell Publishing Country of Publication: England NLM ID: 0214055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8649 (Electronic) Linking ISSN: 00221112 NLM ISO Abbreviation: J Fish Biol Subsets: MEDLINE

Publication: 2003- : Oxford, UK : Blackwell Publishing
Original Publication: London, New York, Published for the Fisheries Society of the British Isles by Academic Press.

Zebrafish*/microbiology ; Microplastics*/toxicity ; Polystyrenes*/toxicity ; Polystyrenes*/adverse effects ; Gastrointestinal Microbiome*/drug effects ; Intestines*/pathology ; Intestines*/microbiology ; Intestines*/drug effects ; Water Pollutants, Chemical*/toxicity ; Water Pollutants, Chemical*/adverse effects; Animals ; Aquaculture ; Diet, High-Fat/adverse effects ; Animal Feed/analysis

The pervasive utilization of plastics and their integration into ecosystems has resulted in significant environmental issues, particularly the pollution of microplastics (MPs). In aquaculture, high-fat feed (HFD) is frequently employed to enhance the energy intake and economic fish production. This study utilized zebrafish as a model organism to investigate the impact of concurrent exposure to HFD and MPs on fish intestinal pathology damage and intestinal microbiome. The experimental design involved the division of zebrafish into two groups: one receiving a normal diet (ND) and the other receiving HFD. The zebrafish were exposed to a control group, as well as polystyrene (PS) MPs of varying sizes (5 and 50 μm). Histopathological examination revealed that the combination of 5 μm MPs and HFD resulted in the most significant damage to the zebrafish intestinal tract. Furthermore, gut microbiome assays indicated that exposure to MPs and HFD altered the composition of the gut microbiome. This study demonstrates that in aquaculture, the issue of HFD must be considered alongside concerns about MPs contamination, as both factors appear to have a combined effect on the intestinal pathology damage and intestinal microbiome. The findings of this research offer valuable insights for the improvement of fish farming practices.
(© 2024 Fisheries Society of the British Isles.)

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Wuhan Talents, Excellent Young Talents Program (2021); Top Medical Young Talents

Keywords: gut microbiota; intestinal injury; polystyrene microplastics; zebrafish

0 (Microplastics)
0 (Polystyrenes)
0 (Water Pollutants, Chemical)

Date Created: 20240410 Date Completed: 20240626 Latest Revision: 20240626

20240627

10.1111/jfb.15746

38596840