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West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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Phone: (843) 552-6466
John L. Dart Library
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Phone: (843) 805-6930
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ENDOGENOUS VERSUS EXOGENOUS ORIGINS OF DISEASES.
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- Author(s): SORNETTE, D.1; YUKALOV, V. I.1,2; YUKALOVA, E. P.3; HENRY, J.-Y.4; SCHWAB, D.5; COBB, J. P.6
- Source:
Journal of Biological Systems. Jun2009, Vol. 17 Issue 2, p225-267. 43p. 11 Graphs.- Subject Terms:
- Source:
- Additional Information
- Abstract: Many illnesses are associated with an alteration of the immune system homeostasis due to a combination of factors, including exogenous bacterial insult, endogenous breakdown (e.g. development of a disease that results in immuno suppression), or an exogenous hit like surgery that simultaneously alters immune responsiveness and provides access to bacteria, or genetic disorder. We conjecture that, as a consequence of the co-evolution of the human immune system with the ecology of pathogens, the homeostasis of the immune system requires the influx of pathogens. This allows the immune system to keep the ever-present pathogens under control and to react and adjust fast to bursts of infections. We construct the simplest and most general system of rate equations which describes the dynamics of five compartments: healthy cells, altered cells, adaptive immune cells, innate immune cells, and pathogens. We study four regimes obtained with or without auto-immune disorder and with or without spontaneous proliferation of infected cells. For each of the four regimes, the phase space is always characterized by four (but not necessary identical) coexisting stationary structurally stable states. Over all four regimes among the 4 × 4 possibilities, there are only seven different states that are naturally described by the model: (i) strong healthy immune system, (ii) healthy organism with evanescent immune cells, (iii) chronic infections, (iv) strong infections, (v) cancer, (vi) critically ill state, and (vii) death. Our description provides a natural framework for describing the relationships and transitions between these seven states. The analysis of stability conditions demonstrates that these seven states depend on the balance between the robustness of the immune system and the influx of pathogens. In particular, the healthy state A is found to exist only under the influence of a sufficiently large pathogen flux, which suggests that health is not the absence of pathogens, but rather a strong ability to find balance by counteracting any pathogen attack. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Biological Systems is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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