Real-world experience of Fuzheng Yiqing granule as chemoprophylaxis against COVID-19 infection among close contacts: A prospective cohort study.

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  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101497477 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-5391 (Electronic) Linking ISSN: 17565391 NLM ISO Abbreviation: J Evid Based Med Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford : Wiley-Blackwell
    • Subject Terms:
      Drugs, Chinese Herbal*/therapeutic use ; COVID-19*/prevention & control ; COVID-19*/epidemiology; Humans ; Prospective Studies ; Male ; Female ; Middle Aged ; Adult ; SARS-CoV-2 ; China/epidemiology ; Quarantine ; COVID-19 Drug Treatment ; Chemoprevention/methods ; Aged ; Young Adult
    • Abstract:
      Background: The objective of the current study was to evaluate whether the use of traditional Chinese medicine, Fuzheng Yiqing granule (FZYQG), was associated with a reduced infection risk of COVID-19 in close contacts.
      Research Design and Methods: This was a prospective cohort study across 203 quarantine centres for close contacts and secondary contacts of COVID-19 patients in Yangzhou city. FZYQG group was defined as quarantined individuals who voluntarily took FZYQG; control group did not take FZYQG. The primary outcome was the coronavirus test positive rate during quarantine period. Logistic regression with propensity score inverse probability weighting was used for adjusted analysis to evaluate independent association between FZYQG and test positive rate.
      Results: From July 13, 2021 to September 30, 2021, 3438 quarantined individuals took FZYQG and 2248 refused to take the granule. Test positive rate was significantly lower among quarantined individuals who took FZYQG (0.29% vs. 1.73%, risk ratio 0.17, 95% confidence interval (CI): 0.08-0.34, p < 0.001). On logistic regression, odds for test positive were decreased in FZYQG group (odds ratio: 0.16, 95% CI: 0.08-0.32, p < 0.001).
      Conclusions: Close and secondary contacts of COVID-19 patients who received FZYQG had a lower test positive rate than control individuals in real-world experience.
      Trial Registration: This study has been registered on Chinese Clinical Trial Registry (ChiCTR2100049590) on August 5, 2021.
      (© 2024 Chinese Cochrane Center, West China Hospital of Sichuan University and John Wiley & Sons Australia, Ltd.)
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    • Grant Information:
      ZZ15-WT-06 China Academy of Chinese Medical Sciences Independent Research Project
    • Contributed Indexing:
      Keywords: COVID‐19; Fuzheng Yiqing Granule; chemoprophylaxis; prevention; traditional Chinese medicine
    • Accession Number:
      0 (Drugs, Chinese Herbal)
    • Publication Date:
      Date Created: 20240409 Date Completed: 20240629 Latest Revision: 20240629
    • Publication Date:
      20240630
    • Accession Number:
      10.1111/jebm.12591
    • Accession Number:
      38591668