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Adipose-derived miRNAs as potential biomarkers for predicting adulthood obesity and its complications: A systematic review and bioinformatic analysis.
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- Author(s): Liu X;Liu X;Liu X; Sun H; Sun H; Sun H; Zheng L; Zheng L; Zheng L; Zhang J; Zhang J; Zhang J; Su H; Su H; Su H; Li B; Li B; Li B; Wu Q; Wu Q; Wu Q; Liu Y; Liu Y; Liu Y; Xu Y; Xu Y; Xu Y; Song X; Song X; Song X; Yu Y; Yu Y; Yu Y; Yu Y
- Source:
Obesity reviews : an official journal of the International Association for the Study of Obesity [Obes Rev] 2024 Jul; Vol. 25 (7), pp. e13748. Date of Electronic Publication: 2024 Apr 08.- Publication Type:
Systematic Review; Journal Article; Review- Language:
English - Source:
- Additional Information
- Source: Publisher: Blackwell Publishing Country of Publication: England NLM ID: 100897395 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-789X (Electronic) Linking ISSN: 14677881 NLM ISO Abbreviation: Obes Rev Subsets: MEDLINE
- Publication Information: Publication: <2002->: Oxford, UK : Blackwell Publishing
Original Publication: Oxford, UK : Blackwell Science, c2000- - Subject Terms:
- Abstract: Adipose tissue is the first and primary target organ of obesity and the main source of circulating miRNAs in patients with obesity. This systematic review aimed to analyze and summarize the generation and mechanisms of adipose-derived miRNAs and their role as early predictors of various obesity-related complications. Literature searches in the PubMed and Web of Science databases using terms related to miRNAs, obesity, and adipose tissue. Pre-miRNAs from the Human MicroRNA Disease Database, known to regulate obesity-related metabolic disorders, were combined for intersection processing. Validated miRNA targets were sorted through literature review, and enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes via the KOBAS online tool, disease analysis, and miRNA transcription factor prediction using the TransmiR v. 2.0 database were also performed. Thirty miRNAs were identified using both obesity and adipose secretion as criteria. Seventy-nine functionally validated targets associated with 30 comorbidities of these miRNAs were identified, implicating pathways such as autophagy, p53 pathways, and inflammation. The miRNA precursors were analyzed to predict their transcription factors and explore their biosynthesis mechanisms. Our findings offer potential insights into the epigenetic changes related to adipose-driven obesity-related comorbidities.
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- Contributed Indexing: Keywords: adipose tissue; circulating miRNAs; comorbidity; obesity
- Accession Number: 0 (MicroRNAs)
0 (Biomarkers) - Publication Date: Date Created: 20240409 Date Completed: 20240607 Latest Revision: 20240613
- Publication Date: 20240613
- Accession Number: 10.1111/obr.13748
- Accession Number: 38590187
- Source:
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