How Would You Manage HIV Pre-exposure Prophylaxis in This Patient With Medical Comorbidities? : Grand Rounds Discussion From Beth Israel Deaconess Medical Center.

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  • Additional Information
    • Source:
      Publisher: American College of Physicians--American Society of Internal Medicine Country of Publication: United States NLM ID: 0372351 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-3704 (Electronic) Linking ISSN: 00034819 NLM ISO Abbreviation: Ann Intern Med Subsets: MEDLINE
    • Publication Information:
      Publication: <2001->: Philadelphia, PA : American College of Physicians--American Society of Internal Medicine
      Original Publication: Philadelphia [etc.] American College of Physicians.
    • Subject Terms:
      HIV Infections*/drug therapy ; HIV Infections*/prevention & control ; Pre-Exposure Prophylaxis* ; Teaching Rounds* ; Acquired Immunodeficiency Syndrome*/drug therapy ; Anti-HIV Agents*/therapeutic use; Humans ; United States ; Anti-Retroviral Agents/therapeutic use
    • Abstract:
      Despite advances in treatment, HIV infection remains an important cause of morbidity and mortality, with more than 30 000 new cases diagnosed in the United States each year. There are several interventions traditionally used to prevent HIV transmission, but these vary in effectiveness and there are challenges to their implementation. In 2014, the Centers for Disease Control and Prevention published initial guidance on the use of antiretroviral pre-exposure prophylaxis (PrEP) to prevent transmission of HIV infection in persons at risk based on multiple studies that showed it to be highly efficacious in various populations. It was updated in 2021 to reflect new drug options. The U.S. Preventive Services Task Force also recently updated its recommendations for PrEP, which strongly support its use in persons at risk. Despite its well-established effectiveness, the implementation of PrEP in clinical practice has been variable, especially among populations underserved by the medical system and marginalized by society. Fewer than one third of persons in the United States who are eligible for PrEP currently receive it. Here, 2 physicians experienced in HIV PrEP debate how best to identify patients who might benefit from PrEP, how to decide what regimen to use, and how to monitor therapy.
      Competing Interests: Disclosures: All relevant financial relationships have been mitigated. Disclosures can also be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M24-0217.
    • Accession Number:
      0 (Anti-Retroviral Agents)
      0 (Anti-HIV Agents)
    • Publication Date:
      Date Created: 20240408 Date Completed: 20240417 Latest Revision: 20240417
    • Publication Date:
      20240417
    • Accession Number:
      10.7326/M24-0217
    • Accession Number:
      38588544