Systematic analyses of the factors influencing sperm quality in patients with SARS-CoV-2 infection.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
      Infertility, Male* ; COVID-19*; Humans ; Male ; Semen Analysis ; Semen ; Prospective Studies ; Sperm Motility ; SARS-CoV-2 ; Spermatozoa ; Sperm Count
    • Abstract:
      To figure out how does SARS-CoV-2 affect sperm parameters and what influencing factors affect the recovery of sperm quality after infection? We conducted a prospective cohort study and initially included 122 men with SARS-CoV-2 infection. The longest time to track semen quality after infection is 112 days and 58 eligible patients were included in our study eventually. We subsequently exploited a linear mixed-effects model to statistically analyze their semen parameters at different time points before and after SARS-CoV-2 infection. Semen parameters were significantly reduced after SARS-CoV-2 infection, including total sperm count (211 [147; 347] to 167 [65.0; 258], P < 0.001), sperm concentration (69.0 [38.8; 97.0] to 51.0 [25.5; 71.5], P < 0.001), total sperm motility (57.5 [52.3; 65.0] to 51.0 [38.5; 56.8], P < 0.001), progressive motility (50.0 [46.2; 58.0] to 45.0 [31.5; 52.8], P < 0.001). The parameters displayed the greatest diminution within 30 days after SARS-CoV-2 infection, gradually recovered thereafter, and exhibited no significant difference after 90 days compared with prior to COVID-19 infection. In addition, the patients in the group with a low-grade fever showed a declining tendency in semen parameters, but not to a significant degree, whereas those men with a moderate or high fever produced a significant drop in the same parameters. Semen parameters were significantly reduced after SARS-CoV-2 infection, and fever severity during SARS-CoV-2 infection may constitute the main influencing factor in reducing semen parameters in patients after recovery, but the effect is reversible and the semen parameters gradually return to normal with the realization of a new spermatogenic cycle.
      (© 2024. The Author(s).)
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    • Grant Information:
      2023NSFSC1603 Youth Fund of Sichuan Natural Science Foundation; BX202208 Sichuan Province Innovative Talent Funding Project for Postdoctoral Fellows; CYZYB22-12 school science and technology fund of Chengdu Medical College
    • Contributed Indexing:
      Keywords: Fever; Linear mixed-effects model; SARS-CoV-2; Semen parameters
    • Publication Date:
      Date Created: 20240407 Date Completed: 20240409 Latest Revision: 20240410
    • Publication Date:
      20240410
    • Accession Number:
      PMC10999436
    • Accession Number:
      10.1038/s41598-024-58797-y
    • Accession Number:
      38584153