Congenital Cataracts With Thin Lenses (Leptophakia) in Children: Morphology and Surgical Outcomes.

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  • Author(s): Zhang MG;Zhang MG; Gallo RA; Gallo RA; Chang TC; Chang TC
  • Source:
    American journal of ophthalmology [Am J Ophthalmol] 2024 Sep; Vol. 265, pp. 1-5. Date of Electronic Publication: 2024 Apr 04.
  • Publication Type:
    Journal Article; Comparative Study
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: United States NLM ID: 0370500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1891 (Electronic) Linking ISSN: 00029394 NLM ISO Abbreviation: Am J Ophthalmol Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : New York, NY : Elsevier Science
      Original Publication: [Chicago, etc., Ophthalmic Pub. Co., etc.]
    • Subject Terms:
      Cataract*/congenital ; Cataract*/physiopathology ; Cataract*/complications ; Visual Acuity*/physiology ; Lens Implantation, Intraocular* ; Lens, Crystalline* ; Cataract Extraction* ; Intraocular Pressure*/physiology; Humans ; Retrospective Studies ; Female ; Male ; Child, Preschool ; Infant ; Child ; Axial Length, Eye/pathology ; Treatment Outcome ; Follow-Up Studies ; Lenses, Intraocular
    • Abstract:
      Purpose: To determine the morphology and postoperative outcomes of pediatric cataracts with thin (leptophakic) lenses.
      Design: Retrospective comparative clinical cohort study.
      Methods: We identified the records of pediatric patients who had undergone cataract surgery between 2018 and 2023 and lens thickness less than 2 standard deviations of age-stratified normal eyes in the general population. Matching controls were identified based on sex, age at surgery, and intraocular lens implant status. Data abstracted include axial length, anterior chamber depth, lens thickness, visual acuity, intraocular pressure, and surgical details.
      Results: A total of 13 eyes from 7 patients were identified to be leptophakic, 8 of which had matching controls. Compared with the control eyes, leptophakic eyes had thinner lenses (2.74 ± 0.39 mm vs 4.82 ± 1.01 mm, P < .01) with comparable anterior chamber depth (3.28 ± 0.76 mm vs 2.98 ± 1.28 mm, P = .13) and axial lengths (19.17 ± 2.61 mm vs 20.76 ± 1.76 mm, P = .20). Following cataract surgery, visual acuity improved for both the leptophakic and control cohorts within 2.5 months postoperatively (-0.68 ± 0.37 logMAR vs -0.06 ± 0.42 logMAR, P = .03) and at 1-2 years postoperatively (-1.58 ± 1.03 logMAR vs -0.60 ± 0.49 logMAR, P = .22) without any glaucoma-related adverse events. Of note, 5 of 13 leptophakic eyes (38%) were found to have posterior capsular ruptures intraoperatively.
      Conclusions: Leptophakic eyes demonstrated similar intraoperative and short-term postoperative outcomes when compared to control eyes, although vigilance for posterior capsular defects and ruptures may be necessary.
      (Copyright © 2024 Elsevier Inc. All rights reserved.)
    • Publication Date:
      Date Created: 20240406 Date Completed: 20240822 Latest Revision: 20240822
    • Publication Date:
      20240823
    • Accession Number:
      10.1016/j.ajo.2024.03.027
    • Accession Number:
      38582306