Comparative hepato-ameliorative effects of Bambusa nutans fresh and fermented shoot extracts on STZ induced diabetic LACA mice.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Oxford : Pergamon Press
    • Subject Terms:
      Plant Extracts*/pharmacology ; Plant Extracts*/chemistry ; Plant Extracts*/therapeutic use ; Fermentation* ; Diabetes Mellitus, Experimental*/drug therapy ; Diabetes Mellitus, Experimental*/metabolism ; Bambusa*/chemistry ; Plant Shoots*/chemistry ; Liver*/drug effects ; Liver*/metabolism ; Liver*/pathology; Animals ; Mice ; Male ; Antioxidants/pharmacology ; Streptozocin ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/chemistry ; Blood Glucose/metabolism ; Blood Glucose/analysis ; Blood Glucose/drug effects
    • Abstract:
      Bamboo shoots are nutritionally rich source of antioxidants and bioactive compounds with immense therapeutic potentials. The fresh shoot is acrid and needs to be processed to make it palatable. Fermentation is one the best processing methods for long term storage and make the shoot palatable and enhance taste. This study aims to assess the prophylactic hepatoprotective effects of fresh and fermented B. nutans shoot aqueous extract (200 mg/kg b.w.) in STZ induced diabetic LACA mice. Both extracts effectively improved body weight loss, hyperglycemia, and hepatomegaly. Fresh shoot reduced LDH activity and LPO level by 26.1% and 46.6%, while fermented shoot reduced them by 51.5% and 55.8%, respectively. The fermented shoot extract group demonstrated a noteworthy decrease in liver enzymes (SGPT, SGOT, ALP, and bilirubin levels) and an increase in albumin and A/G ratio, with more substantial improvements compared to the group treated with fresh extract. Additionally, the extracts enhanced antioxidant activities and showed histological improvements in hepatocytes and central vein structure. The findings indicate that both fresh and fermented B. nutans extracts are non-toxic and possess hepatoprotective potential in hyperglycaemic liver dysfunction, with fermented shoot extract exhibiting superior efficacy suggesting its potential as a therapeutic agent for hyperglycemic liver conditions.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Antioxidant activity; B. nutans; Fresh and fermented shoots; Hepatoprotection; STZ-Induced diabetes
    • Accession Number:
      0 (Plant Extracts)
      0 (Antioxidants)
      5W494URQ81 (Streptozocin)
      0 (Hypoglycemic Agents)
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20240405 Date Completed: 20240503 Latest Revision: 20240503
    • Publication Date:
      20240503
    • Accession Number:
      10.1016/j.talanta.2024.126035
    • Accession Number:
      38579421