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Impaired erythropoietin response to hypoxia in type 2 diabetes.
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- Author(s): Wojan F;Wojan F; Stray-Gundersen S; Stray-Gundersen S; Zhao J; Zhao J; Lalande S; Lalande S
- Source:
Acta diabetologica [Acta Diabetol] 2024 Jul; Vol. 61 (7), pp. 925-932. Date of Electronic Publication: 2024 Apr 04.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
- Publication Information: Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991- - Subject Terms: Diabetes Mellitus, Type 2*/metabolism ; Diabetes Mellitus, Type 2*/physiopathology ; Diabetes Mellitus, Type 2*/complications ; Diabetes Mellitus, Type 2*/blood ; Erythropoietin*/blood ; Erythropoietin*/metabolism ; Hypoxia*/physiopathology ; Hypoxia*/metabolism; Humans ; Male ; Female ; Middle Aged ; Aged ; Hemoglobins/metabolism ; Hemoglobins/analysis ; Oxygen/metabolism ; Oxygen/blood
- Abstract: Aims: Patients with type 2 diabetes have a 20% lower total blood volume than age- and weight-matched healthy adults, suggesting a reduced capacity to transport oxygen in this population. Intermittent hypoxia, consisting of alternating short bouts of breathing hypoxic and normoxic air, increases erythropoietin levels, the hormone regulating red blood cell production, in young and older adults. The objective of this study was to determine the effect of a single session of intermittent hypoxia on erythropoietin levels and hemoglobin mass, the absolute mass of hemoglobin contained in red blood cells, in patients with type 2 diabetes.
Methods: Ten patients with type 2 diabetes were exposed to an intermittent hypoxia protocol consisting of eight 4-min cycles at a targeted oxygen saturation of 80% interspersed with normoxic cycles to resaturation. Erythropoietin and hemoglobin mass responses to intermittent hypoxia in patients with type 2 diabetes were compared to previously published data from an identical intermittent hypoxia protocol performed in age-matched older adults.
Results: Intermittent hypoxia increased erythropoietin levels in older adults but did not induce any change in erythropoietin levels in patients with type 2 diabetes (3.2 ± 2.2 vs. 0.2 ± 2.7 mU/ml, p = 0.01). Hemoglobin mass indexed to body weight was 21% lower in patients with type 2 diabetes than in older adults (8.1 ± 1.7 vs. 10.2 ± 2.1 g/kg, p < 0.01).
Conclusions: These findings suggest an impaired erythropoietin response to decreased oxygen levels in patients with type 2 diabetes, which may contribute to the reduced oxygen transport capacity observed in this population.
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Takiyama Y, Harumi T, Watanabe J et al (2011) Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1alpha expression and oxygen metabolism. Diabetes 60(3):981–992. https://doi.org/10.2337/db10-0655. (PMID: 10.2337/db10-0655212823693046859) - Contributed Indexing: Keywords: Erythropoietin; Hemoglobin mass; Intermittent hypoxia; Type 2 diabetes
- Molecular Sequence: ClinicalTrials.gov NCT05898685
- Accession Number: 11096-26-7 (Erythropoietin)
0 (Hemoglobins)
0 (EPO protein, human)
S88TT14065 (Oxygen) - Publication Date: Date Created: 20240403 Date Completed: 20240617 Latest Revision: 20240703
- Publication Date: 20240703
- Accession Number: 10.1007/s00592-024-02269-2
- Accession Number: 38570345
- Source:
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