Impaired erythropoietin response to hypoxia in type 2 diabetes.

Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE

Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991-

Diabetes Mellitus, Type 2*/metabolism ; Diabetes Mellitus, Type 2*/physiopathology ; Diabetes Mellitus, Type 2*/complications ; Diabetes Mellitus, Type 2*/blood ; Erythropoietin*/blood ; Erythropoietin*/metabolism ; Hypoxia*/physiopathology ; Hypoxia*/metabolism; Humans ; Male ; Female ; Middle Aged ; Aged ; Hemoglobins/metabolism ; Hemoglobins/analysis ; Oxygen/metabolism ; Oxygen/blood

Aims: Patients with type 2 diabetes have a 20% lower total blood volume than age- and weight-matched healthy adults, suggesting a reduced capacity to transport oxygen in this population. Intermittent hypoxia, consisting of alternating short bouts of breathing hypoxic and normoxic air, increases erythropoietin levels, the hormone regulating red blood cell production, in young and older adults. The objective of this study was to determine the effect of a single session of intermittent hypoxia on erythropoietin levels and hemoglobin mass, the absolute mass of hemoglobin contained in red blood cells, in patients with type 2 diabetes.
Methods: Ten patients with type 2 diabetes were exposed to an intermittent hypoxia protocol consisting of eight 4-min cycles at a targeted oxygen saturation of 80% interspersed with normoxic cycles to resaturation. Erythropoietin and hemoglobin mass responses to intermittent hypoxia in patients with type 2 diabetes were compared to previously published data from an identical intermittent hypoxia protocol performed in age-matched older adults.
Results: Intermittent hypoxia increased erythropoietin levels in older adults but did not induce any change in erythropoietin levels in patients with type 2 diabetes (3.2 ± 2.2 vs. 0.2 ± 2.7 mU/ml, p = 0.01). Hemoglobin mass indexed to body weight was 21% lower in patients with type 2 diabetes than in older adults (8.1 ± 1.7 vs. 10.2 ± 2.1 g/kg, p < 0.01).
Conclusions: These findings suggest an impaired erythropoietin response to decreased oxygen levels in patients with type 2 diabetes, which may contribute to the reduced oxygen transport capacity observed in this population.
(© 2024. Springer-Verlag Italia S.r.l., part of Springer Nature.)

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Keywords: Erythropoietin; Hemoglobin mass; Intermittent hypoxia; Type 2 diabetes

ClinicalTrials.gov NCT05898685

11096-26-7 (Erythropoietin)
0 (Hemoglobins)
0 (EPO protein, human)
S88TT14065 (Oxygen)

Date Created: 20240403 Date Completed: 20240617 Latest Revision: 20240703

20240703

10.1007/s00592-024-02269-2

38570345