An Increase in Vascular Stiffness Is Positively Associated With Mitochondrial Bioenergetics Impairment of Peripheral Blood Mononuclear Cells in the Older Adults.

Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE

Publication: Washington, DC : published on behalf of the Gerontological Society of America by Oxford University Press
Original Publication: Washington, DC : Gerontological Society of America, c1995-

Energy Metabolism*/physiology ; Leukocytes, Mononuclear*/metabolism ; Mitochondria*/metabolism ; Vascular Stiffness*/physiology; Humans ; Male ; Female ; Aged ; Cross-Sectional Studies ; Ankle Brachial Index ; Thailand ; Cardio Ankle Vascular Index ; Middle Aged

The cardio-ankle vascular index (CAVI) is a noninvasive parameter reflecting vascular stiffness. CAVI correlates with the burden of atherosclerosis and future cardiovascular events. Mitochondria of peripheral blood mononuclear cells (PBMCs) have been identified as a noninvasive source for assessing systemic mitochondrial bioenergetics. This study aimed to investigate the relationship between CAVI values and mitochondrial bioenergetics of PBMCs in the older adults.. This cross-sectional study enrolled participants from the Electricity Generating Authority of Thailand between 2017 and 2018. A total of 1 640 participants with an ankle-brachial index greater than 0.9 were included in this study. All participants were stratified into 3 groups based on their CAVI values as high (CAVI ≥ 9), moderate (9 > CAVI ≥ 8), and low (CAVI < 8), in which each group comprised 702, 507, and 431 participants, respectively. The extracellular flux analyzer was used to measure mitochondrial respiration of isolated PBMCs. The mean age of the participants was 67.9 years, and 69.6% of them were male. After adjusted with potential confounders including age, sex, smoking status, body mass index, diabetes, dyslipidemia, hypertension, and creatinine clearance, participants with high CAVI values were independently associated with impaired mitochondrial bioenergetics, including decreased basal respiration, maximal respiration, and spare respiratory capacity, as well as increased mitochondrial reactive oxygen species. This study demonstrated that CAVI measurement reflects the underlying impairment of cellular mitochondrial bioenergetics in PBMCs. Further longitudinal studies are necessary to establish both a causal relationship between CAVI measurement and underlying cellular dysfunction.
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N42A660301 National Research Council of Thailand; National Research Council of Thailand; Chiang Mai University Center of Excellence Award; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Thailand Science Research and Innovation; Thai Heart Association; Thai Health Foundation; Higher Education Research Promotion and National Research University Development; Centro de Investigação em Ciências Sociais; Cooperative Research Network; Health Systems Research Institute

Keywords: Cardio-ankle vascular index; Cardiovasular; Mitochondria; Peripheral blood mononuclear cells

Date Created: 20240403 Date Completed: 20240620 Latest Revision: 20240620

20240620

10.1093/gerona/glae095

38567632