Comparison of the optical coherence tomography-angiography (OCT-A) vascular measurements between molecularly confirmed MODY and age-matched healthy controls.

Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE

Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991-

Tomography, Optical Coherence*/methods ; Diabetes Mellitus, Type 2*/genetics ; Diabetes Mellitus, Type 2*/diagnostic imaging ; Retinal Vessels*/diagnostic imaging; Humans ; Male ; Female ; Adolescent ; Child ; Case-Control Studies ; Diabetic Retinopathy/diagnostic imaging ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/genetics ; Young Adult ; Fluorescein Angiography/methods ; Glucokinase/genetics ; Macula Lutea/diagnostic imaging ; Macula Lutea/blood supply

Aims: Previous structural, vascular density, and perfusion studies have mostly comprised type 1 and type 2 diabetes, even in the absence of retinopathy. The current study aimed to compare macular vessel density (VD) measurements between maturity-onset diabetes of the young (MODY) patients and controls.
Methods: The macular VD of superficial, deep retina, and choriocapillaris (CC), and central macular thickness (CMT), foveal avascular zone (FAZ), FAZ perimetry, VD of the total retina at 300 µm around the FAZ (FD), and acirculatory index (AI) measurements were taken and analyzed via OCT-A (RTVue XR 100-2 Avanti, AngioVue) and were compared between molecularly confirmed MODY (glucokinase (GCK) variants) patients and healthy controls.
Results: Twenty-five MODY patients and 30 healthy controls were included in the study. The mean plasma hemoglobin A1c level in the MODY group was 6.39 ± 0.38. The mean age was 13.8 ± 2.1 in the MODY group and was 12.6 ± 2.5 years among controls. There was no significant difference in terms of the age, superficial and deep retinal VD, FAZ, FAZ perimetry, CMT, FD, or AI between the groups. Compared to the healthy controls, a slight but significant increase in the CC-VD was detected in the MODY group, but only in the parafoveal and perifoveal regions (p = 0.034, p = 0.009).
Conclusion: The significant CC-VD increase in the MODY group might be associated with hyperglycemia and/or relatively poor and vulnerable peripheral vascular CC perfusion compared to the central. Previous thickness and VD results of childhood or adolescent diabetes were distributed in a wider range, suggesting that various factors, including some not yet clearly defined, may affect the choroidal vasculature independently of glycemia or as a contributing factor.
(© 2024. Springer-Verlag Italia S.r.l., part of Springer Nature.)

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Keywords: Angiography; Density; Diabetes; MODY; Vascular; Vessel

EC 2.7.1.2 (Glucokinase)

Mason-Type Diabetes

Date Created: 20240402 Date Completed: 20240617 Latest Revision: 20240617

20240619

10.1007/s00592-024-02273-6

38565685