Afadin-nectin forces its way to the front.

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  • Author(s): Sebbagh M;Sebbagh M; Schwartz MA; Schwartz MA
  • Source:
    The Journal of cell biology [J Cell Biol] 2024 May 06; Vol. 223 (5). Date of Electronic Publication: 2024 Apr 02.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York : Rockefeller University Press
    • Subject Terms:
      Microfilament Proteins*/metabolism ; Nectins*/metabolism ; Intercellular Junctions*/chemistry; Cadherins/metabolism ; Catenins/metabolism ; Humans
    • Abstract:
      Force transmission at cell-cell junctions critically regulates embryogenesis, tissue homeostasis, and diseases including cancer. The cadherin-catenin linkage has been considered the keystone of junctional force transmission, but new findings challenge this paradigm, arguing instead that the nectin-afadin linkage plays the more important role in mature junctions in the intestinal epithelium.
      (© 2024 Sebbagh and Schwartz.)
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    • Accession Number:
      0 (afadin)
      0 (Cadherins)
      0 (Catenins)
      0 (Microfilament Proteins)
      0 (Nectins)
    • Publication Date:
      Date Created: 20240402 Date Completed: 20240403 Latest Revision: 20241003
    • Publication Date:
      20241003
    • Accession Number:
      PMC10988649
    • Accession Number:
      10.1083/jcb.202403177
    • Accession Number:
      38563860