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Melatonin promotes cell cycle progression of neural stem cells subjected to manganese via Nurr1.
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- Author(s): Chen N;Chen N; Zhou H; Zhou H; He B; He B; Peng S; Peng S; Ding F; Ding F; Liu QH; Liu QH; Ma Z; Ma Z; Ma Z; Liu W; Liu W; Liu W; Xu B; Xu B; Xu B
- Source:
Environmental toxicology [Environ Toxicol] 2024 Jul; Vol. 39 (7), pp. 3883-3896. Date of Electronic Publication: 2024 Apr 02.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 100885357 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-7278 (Electronic) Linking ISSN: 15204081 NLM ISO Abbreviation: Environ Toxicol Subsets: MEDLINE
- Publication Information: Original Publication: New York, NY : John Wiley & Sons, c1999-
- Subject Terms: Neural Stem Cells*/drug effects ; Neural Stem Cells*/metabolism ; Melatonin*/pharmacology ; Nuclear Receptor Subfamily 4, Group A, Member 2*/metabolism ; Nuclear Receptor Subfamily 4, Group A, Member 2*/genetics ; Cell Proliferation*/drug effects ; Manganese*/toxicity ; Cell Cycle*/drug effects; Animals ; Cells, Cultured ; Mice
- Abstract: Excessive exposure to manganese (Mn) through drinking water and food during pregnancy significantly heightens the likelihood of neurodevelopmental damage in offspring. Multiple studies have indicated that melatonin (Mel) may help to relieve neurodevelopmental disorders caused by Mn, but potential mechanisms underlying this effect require further exploration. Here, we utilized primary neural stem cells (NSCs) as a model to elucidate the molecular mechanism underlying the protective function of Mel on Mn-induced cell proliferation dysfunction and cycle arrest. Our results showed that Mn disrupted the cell cycle in NSCs by suppressing positive regulatory proteins (CDK2, Cyclin A, Cyclin D
1 , and E2F1) and enhancing negative ones (p27 KIP1 and p57 KIP2 ), leading to cell proliferation dysfunction. Mel inhibited the Mn-dependent changes to these proteins and the cell cycle through nuclear receptor-related protein 1 (Nurr1), thus alleviating the proliferation dysfunction. Knockdown of Nurr1 using lentivirus-expressed shRNA in NSCs resulted in a diminished protective effect of Mel. We concluded that Mel mitigated Mn-induced proliferation dysfunction and cycle arrest in NSCs through Nurr1.
(© 2024 Wiley Periodicals LLC.) - References: Balachandran RC, Mukhopadhyay S, McBride D, et al. Brain manganese and the balance between essential roles and neurotoxicity. J Biol Chem. 2020;295(19):6312‐6329.
Farías P, Hernández‐Bonilla D, Moreno‐Macías H, et al. Prenatal Co‐exposure to manganese, mercury, and Lead, and neurodevelopment in children during the first year of life. Int J Environ Res Public Health. 2022;19(20):13020.
Shah S, Jeong KS, Park H, et al. Environmental pollutants affecting children's growth and development: collective results from the MOCEH study, a multi‐centric prospective birth cohort in Korea. Environ Int. 2020;137:105547.
Skogheim TS, Weyde KVF, Engel SM, et al. Metal and essential element concentrations during pregnancy and associations with autism spectrum disorder and attention‐deficit/ hyperactivity disorder in children. Environ Int. 2021;152:106468.
Lindner S, Lucchini R, Broberg K. Genetics and epigenetics of manganese toxicity. Curr Environ Health Rep. 2022;9(4):697‐713.
Mira H, Morante J. Neurogenesis from embryo to adult ‐ lessons from flies and mice. Front Cell Dev Biol. 2020;8:533.
Martins‐Macedo J, Lepore AC, Domingues HS, Salgado AJ, Gomes ED, Pinto L. Glial restricted precursor cells in central nervous system disorders: current applications and future perspectives. Glia. 2021;69(3):513‐531.
Costa L, Tempio A, Lacivita E, Leopoldo M, Ciranna L. Serotonin 5‐HT7 receptors require cyclin‐dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of fragile X syndrome. Eur J Neurosci. 2021;54(1):4124‐4132.
Yuan L, Yang Y, Li X, et al. 18β‐glycyrrhetinic acid regulates mitochondrial ribosomal protein L35‐associated apoptosis signaling pathways to inhibit proliferation of gastric carcinoma cells. World J Gastroenterol. 2022;28(22):2437‐2456.
Jablonska B, Adams KL, Kratimenos P, et al. Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia. Nat Commun. 2022;13(1):4771.
Hernroth B, Tassidis H, Baden SP. Immunosuppression of aquatic organisms exposed to elevated levels of manganese: from global to molecular perspective. Dev Comp Immunol. 2020;104:103536.
Hardeland R. Melatonin and the Programming of Stem Cells. Int J Mol Sci. 2022;23(4):1971.
Fu J, Zhao SD, Liu HJ, et al. Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro. J Pineal Res. 2011;51(1):104‐112.
Li HY, Zhang YM, Liu SM, et al. Melatonin enhances proliferation and modulates differentiation of neural stem cells via autophagy in hyperglycemia. Stem Cells. 2019;37(4):504‐515.
Català‐Solsona J, Miñano‐Molina AJ, Rodríguez‐Alvarez J. Nr4a2 transcription factor in hippocampal synaptic plasticity, memory and cognitive dysfunction: a perspective review. Front Mol Neurosci. 2021;14:786226.
Bordoni L, Petracci I, Calleja‐Agius J, Lalor JG, Gabbianelli R. NURR1 alterations in perinatal stress: a first step towards late‐onset diseases? A narrative review. Biomedicine. 2020;8(12):584.
Kim SM, Cho SY, Kim MW, et al. Genome‐wide analysis identifies NURR1‐controlled network of new synapse formation and cell cycle arrest in human neural stem cells. Mol Cells. 2020;43(6):551‐571.
Ghareghani M, Sadeghi H, Zibara K, Danaei N, Azari H, Ghanbari A. Melatonin increases oligodendrocyte differentiation in cultured neural stem cells. Cell Mol Neurobiol. 2017;37(7):1319‐1324.
Yan D, Yu F, Chen LB, et al. Subconjunctival injection of regulatory T cells potentiates corneal healing via orchestrating inflammation and tissue repair after acute alkali burn. Invest Ophthalmol Vis Sci. 2020;61(14):22.
Choi JW, Kang SJ, Choi JI, Kwack KB, Kim MY. Role of nuclear‐receptor‐related 1 in the synergistic neuroprotective effect of umbilical cord blood and erythropoietin combination therapy in hypoxic ischemic encephalopathy. Int J Mol Sci. 2022;23(5):2900.
Zhao J, Yu SZ, Cai Q, et al. Identifying the key genes in mouse liver regeneration after partial hepatectomy by bioinformatics analysis and in vitro/vivo experiments. Front Genet. 2021;12:670706.
Moon H, Jeon SG, Kim JI, et al. Pharmacological stimulation of Nurr1 promotes cell cycle progression in adult hippocampal neural stem cells. Int J Mol Sci. 2019;21(1):4.
Gerber GB, Léonard A, Hantson P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25‐34.
Hu J, Wu CS, Zheng TZ, et al. Critical windows for associations between manganese exposure during pregnancy and size at birth: a longitudinal cohort study in Wuhan, China. Environ Health Perspect. 2018;126(12):127006.
Deng Y, Jiao CC, Mi C, et al. Melatonin inhibits manganese‐induced motor dysfunction and neuronal loss in mice: involvement of oxidative stress and dopaminergic neurodegeneration. Mol Neurobiol. 2015;51(1):68‐88.
Ohtani K, Iwanaga R, Nakamura M, et al. Cell growth‐regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F. Oncogene. 1999;18(14):2299‐2309.
González‐Magaña A, Blanco FJ. Human PCNA structure, function, and interactions. Biomolecules. 2020;10(4):570.
Liu LJ, Michowski W, Kolodziejczyk A, Sicinski P. The cell cycle in stem cell proliferation, pluripotency and differentiation. Nat Cell Biol. 2019;21(9):1060‐1067.
Bo LY, Li TJ, Zhao XH. Copper or manganese supplementation endows the peptic hydrolysate from bovine lactoferrin with enhanced activity to human gastric cancer AGS cells. Biol Trace Elem Res. 2019;189(1):64‐74.
Coller HA. Regulation of cell cycle entry and exit: a single cell perspective. Compr Physiol. 2019;10(1):317‐344.
Qie S, Diehl JA. Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med (Berl). 2016;94(12):1313‐1326.
Roskoski R. Cyclin‐dependent protein kinase inhibitors including palbociclib as anticancer drugs. Pharmacol Res. 2016;107:249‐275.
Ovrebo JI, Bradley‐Gill MR, Zielke N, et al. Translational control of E2f1 regulates the drosophila cell cycle. Proc Natl Acad Sci USA. 2022;119(4):e2113704119.
Tadesse S, Anshabo AT, Portman N, et al. Targeting CDK2 in cancer: challenges and opportunities for therapy. Drug Discov Today. 2020;25(2):406‐413.
Dai L, Liu Y, Liu J, et al. A novel cyclinE/cyclinA‐CDK inhibitor targets p27(Kip1) degradation, cell cycle progression and cell survival: implications in cancer therapy. Cancer Lett. 2013;333(1):103‐112.
Rath SL, Senapati S. Mechanism of p27 unfolding for CDK2 reactivation. Sci Rep. 2016;6:26450.
Sharma SS, Ma L, Pledger WJ. p27Kip1 inhibits the cell cycle through non‐canonical G1/S phase‐specific gatekeeper mechanism. Cell Cycle. 2015;14(24):3954‐3964.
Tocharus C, Puriboriboon Y, Junmanee T, Tocharus J, Ekthuwapranee K, Govitrapong P. Melatonin enhances adult rat hippocampal progenitor cell proliferation via Erk signaling pathway through melatonin receptor. Neuroscience. 2014;275:314‐321.
Xu GQ, Zhao J, Liu HY, Wang J, Lu W. Melatonin inhibits apoptosis and oxidative stress of mouse Leydig cells via a SIRT1‐dependent mechanism. Molecules. 2019;24(17):3084.
Sharma R, Ottenhof T, Rzeczkowska PA, Niles LP. Epigenetic targets for melatonin: induction of histone H3 hyperacetylation and gene expression in C17.2 neural stem cells. J Pineal Res. 2008;45(3):277‐284.
Shukla M, Vincent B. Melatonin as a Harmonizing Factor of Circadian Rhythms, Neuronal Cell Cycle and Neurogenesis: Additional Arguments for Its Therapeutic Use in Alzheimer's Disease. Curr Neuropharmacol. 2023;21(5):1273‐1298.
Pan B, Yang HX, Wu ZZ, et al. Melatonin improves parthenogenetic development of vitrified‐warmed mouse oocytes potentially by promoting G1/S cell cycle progression. Int J Mol Sci. 2018;19(12):4029.
Wan PK, Siu MK, Leung TH, et al. Role of Nurr1 in carcinogenesis and tumor immunology: a state of the art review. Cancers (Basel). 2020;12(10):3044.
Dodat F, Mader S, Lévesque D. Minireview: What is known about SUMOylation among NR4A family members? J Mol Biol. 2021;433(21):167212.
Li X, Tai HH. Activation of thromboxane a(2) receptors induces orphan nuclear receptor Nurr1 expression and stimulates cell proliferation in human lung cancer cells. Carcinogenesis. 2009;30(9):1606‐1613. - Contributed Indexing: Keywords: cell cycle; manganese; melatonin; neural stem cells; nuclear receptor‐related protein 1
- Accession Number: JL5DK93RCL (Melatonin)
0 (Nuclear Receptor Subfamily 4, Group A, Member 2)
42Z2K6ZL8P (Manganese)
0 (Nr4a2 protein, mouse) - Publication Date: Date Created: 20240402 Date Completed: 20240611 Latest Revision: 20240621
- Publication Date: 20240621
- Accession Number: 10.1002/tox.24258
- Accession Number: 38563506
- Source:
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