Research progress on mechanism of follicle injury after ovarian tissue transplantation and protective strategies.

移植卵巢组织卵泡损伤机制及保护策略.

Publisher: Zhejiang da xue xue bao bian ji bu Country of Publication: China NLM ID: 100927946 Publication Model: Electronic Cited Medium: Print ISSN: 1008-9292 (Print) Linking ISSN: 10089292 NLM ISO Abbreviation: Zhejiang Da Xue Xue Bao Yi Xue Ban Subsets: MEDLINE

Original Publication: Hangzhou : Zhejiang da xue xue bao bian ji bu, [1999]-

Ovarian Follicle* ; Cryopreservation*/methods ; Ovary*/transplantation ; Fertility Preservation*/methods; Female ; Humans ; Reperfusion Injury/prevention & control ; Reperfusion Injury/etiology ; Animals

Ovarian tissue cryopreservation and transplantation is the only way to preserve fertility for female cancer patients in prepubertal ages and those who cannot delay radiotherapy or chemotherapy. However, the success rate of cryopreservation and transplantation of ovarian tissue is still low at present due to the risk of ischemia and hypoxia of the grafted tissues. Abnormal activation of primordial follicles and ischemia-reperfusion injury after blood supply recovery also cause massive loss of follicles in grafted ovarian tissues. Various studies have explored the use of different drugs to reduce the damage of follicles during freezing and transplantation as well as to extend the duration of endocrine and reproductive function in patients with ovarian transplantation. For example, melatonin, N -acetylcysteine, erythropoietin or other antioxidants have been used to reduce oxidative stress; mesenchymal stem cells derived from different tissues, basic fibroblast growth factor, vascular endothelial growth factor, angiopoietin 2 and gonadotropin have been used to promote revascularization; anti-Müllerian hormone and rapamycin have been used to reduce abnormal activation of primordial follicles. This article reviews the research progress on the main mechanisms of follicle loss after ovarian tissue transplantation, including hypoxia, ischemia-reperfusion injury and associated cell death, and abnormal activation of follicles. The methods for reducing follicle loss in grafted ovarian tissues are further explored to provide a reference for improving the efficiency of ovarian tissue cryopreservation and transplantation.

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Keywords: Cryopreservation; Follicle activation; Follicle injury; Ovarian tissue; Review; Transplantation
Local Abstract: [Publisher, Chinese] 卵巢组织冷冻保存及移植是青春期前女性及不能延迟放疗或化疗的恶性肿瘤患者唯一的生育力保存手段。目前，卵巢组织冷冻保存及移植效率仍低，卵巢组织移植后面临缺血缺氧风险，始基卵泡的异常激活和血供恢复后的缺血-再灌注损伤也造成移植卵巢组织卵泡大量损失。大量研究尝试通过添加某些药物减少卵泡在冷冻及移植过程中所受的损伤，延长卵巢移植患者内分泌功能及生殖功能持续的时间：如添加褪黑素、 N -乙酰半胱氨酸、促红细胞生成素或其他抗氧化剂以减轻氧化应激，添加不同来源的间充质干细胞、碱性成纤维细胞生长因子、血管内皮生长因子、血管生成素2、促性腺激素以促进血运重建，添加抗米勒管激素、雷帕霉素以减少始基卵泡异常激活。本文重点阐述了卵巢组织移植后卵泡损伤的主要机制及减少移植卵巢组织卵泡损伤的方法，以期为提高卵巢组织移植效率提供参考。.

Date Created: 20240402 Date Completed: 20240826 Latest Revision: 20240829

20240830

PMC11348700

10.3724/zdxbyxb-2023-0566

38562041