The effects of citrus flavonoids supplementation on endothelial function: A systematic review and dose-response meta-analysis of randomized clinical trials.

Publisher: Wiley Country of Publication: England NLM ID: 8904486 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1573 (Electronic) Linking ISSN: 0951418X NLM ISO Abbreviation: Phytother Res Subsets: MEDLINE

Publication: : Chichester : Wiley
Original Publication: London : Heyden & Son, c1987-

Citrus*/chemistry ; Flavonoids*/pharmacology ; Randomized Controlled Trials as Topic* ; Vasodilation*/drug effects ; Endothelium, Vascular*/drug effects ; Dietary Supplements*; Humans ; Dose-Response Relationship, Drug

The present systematic review and dose-response meta-analysis was conducted to synthesize existing data from randomized clinical trials (RCTs) concerning the impact of citrus flavonoids supplementation (CFS) on endothelial function. Relevant RCTs were identified through comprehensive searches of the PubMed, ISI Web of Science, and Scopus databases up to May 30, 2023. Weighted mean differences and their corresponding 95% confidence intervals (CI) were pooled utilizing a random-effects model. A total of eight eligible RCTs, comprising 596 participants, were included in the analysis. The pooled data demonstrated a statistically significant augmentation in flow-mediated vasodilation (FMD) (2.75%; 95% CI: 1.29, 4.20; I ²  = 87.3%; p < 0.001) associated with CFS compared to the placebo group. Furthermore, the linear dose-response analysis indicated that each increment of 200 mg/d in CFS led to an increase of 1.09% in FMD (95% CI: 0.70, 1.48; I ²  = 94.5%; p < 0.001). The findings from the nonlinear dose-response analysis also revealed a linear relationship between CFS and FMD (P non-linearity  = 0.903, P dose-response  <0.001). Our findings suggest that CFS enhances endothelial function. However, more extensive RTCs encompassing longer intervention durations and different populations are warranted to establish more precise conclusions.
(© 2024 John Wiley & Sons Ltd.)

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Keywords: FMD; citrus flavonoids; dose–response meta‐analysis; endothelial function

0 (Flavonoids)

Date Created: 20240402 Date Completed: 20240612 Latest Revision: 20240613

20240614

10.1002/ptr.8190

38561995