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Reports of COVID-19 Vaccine Adverse Events in Predominantly Republican vs Democratic States.
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- Author(s): Asch DA;Asch DA;Asch DA; Luo C; Luo C; Chen Y; Chen Y; Chen Y; Chen Y
- Source:
JAMA network open [JAMA Netw Open] 2024 Mar 04; Vol. 7 (3), pp. e244177. Date of Electronic Publication: 2024 Mar 04.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
- Publication Information: Original Publication: Chicago, IL : American Medical Association, [2018]-
- Subject Terms:
- Abstract: Importance: Antivaccine sentiment is increasingly associated with conservative political positions. Republican-inclined states exhibit lower COVID-19 vaccination rates, but the association between political inclination and reported vaccine adverse events (AEs) is unexplored.
Objective: To assess whether there is an association between state political inclination and the reporting rates of COVID-19 vaccine AEs.
Design, Setting, and Participants: This cross-sectional study used the AE reports after COVID-19 vaccination from the Vaccine Adverse Event Reporting System (VAERS) database from 2020 to 2022, with reports after influenza vaccines from 2019 to 2022 used as a reference. These reports were examined against state-level percentage of Republican votes in the 2020 US presidential election.
Exposure: State-level percentage of Republican votes in the 2020 US presidential election.
Main Outcomes and Measures: Rates of any AE among COVID-19 vaccine recipients, rates of any severe AE among vaccine recipients, and the proportion of AEs reported as severe.
Results: A total of 620 456 AE reports (mean [SD] age of vaccine recipients, 51.8 [17.6] years; 435 797 reports from women [70.2%]; a vaccine recipient could potentially file more than 1 report, so reports are not necessarily from unique individuals) for COVID-19 vaccination were identified from the VAERS database. Significant associations between state political inclination and state AE reporting were observed for all 3 outcomes: a 10% increase in Republican voting was associated with increased odds of AE reports (odds ratio [OR], 1.05; 95% CI, 1.05-1.05; P < .001), severe AE reports (OR, 1.25; 95% CI, 1.24-1.26; P < .001), and the proportion of AEs reported as severe (OR, 1.21; 95% CI, 1.20-1.22; P < .001). These associations were seen across all age strata in stratified analyses and were more pronounced among older subpopulations.
Conclusions and Relevance: This cross-sectional study found that the more states were inclined to vote Republican, the more likely their vaccine recipients or their clinicians reported COVID-19 vaccine AEs. These results suggest that either the perception of vaccine AEs or the motivation to report them was associated with political inclination. - References: Lancet Reg Health Am. 2022 Dec;16:100384. (PMID: 36338898)
Public Health Rep. 1997 Jan-Feb;112(1):10-20; discussion 21. (PMID: 9018282)
Stat Med. 2002 Feb 15;21(3):371-87. (PMID: 11813224)
Vaccine. 1999 Jul 16;17(22):2908-17. (PMID: 10438063)
JAMA Netw Open. 2024 Mar 4;7(3):e244177. (PMID: 38551560)
Vaccine. 2022 Mar 25;40(14):2191-2201. (PMID: 35227522)
Vaccine. 1994 May;12(6):542-50. (PMID: 8036829) - Accession Number: 0 (COVID-19 Vaccines)
0 (Influenza Vaccines) - Publication Date: Date Created: 20240329 Date Completed: 20240401 Latest Revision: 20240401
- Publication Date: 20240402
- Accession Number: PMC10980960
- Accession Number: 10.1001/jamanetworkopen.2024.4177
- Accession Number: 38551560
- Source:
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