Associations between polygenic liability to psychopathology and non-suicidal versus suicidal self-injury.

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  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101235742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-485X (Electronic) Linking ISSN: 15524841 NLM ISO Abbreviation: Am J Med Genet B Neuropsychiatr Genet Subsets: MEDLINE
    • Publication Information:
      Publication: Hoboken, N.J. : Wiley-Blackwell
      Original Publication: Hoboken, N.J. : Wiley-Liss, c2003-
    • Subject Terms:
      Multifactorial Inheritance*/genetics ; Self-Injurious Behavior*/genetics ; Self-Injurious Behavior*/psychology ; Suicide, Attempted*/psychology ; Genetic Predisposition to Disease*; Humans ; Female ; Male ; Middle Aged ; Psychopathology ; Adult ; Suicidal Ideation ; Aged ; Anorexia Nervosa/genetics ; Anorexia Nervosa/psychology ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Genome-Wide Association Study ; United Kingdom ; Risk Factors
    • Abstract:
      Little is known about how non-suicidal and suicidal self-injury are differentially genetically related to psychopathology and related measures. This research was conducted using the UK Biobank Resource, in participants of European ancestry (N = 2320 non-suicidal self-injury [NSSI] only; N = 2648 suicide attempt; 69.18% female). We compared polygenic scores (PGS) for psychopathology and other relevant measures within self-injuring individuals. Logistic regressions and likelihood ratio tests (LRT) were used to identify PGS that were differentially associated with these outcomes. In a multivariable model, PGS for anorexia nervosa (odds ratio [OR] = 1.07; 95% confidence intervals [CI] 1.01; 1.15) and suicidal behavior (OR = 1.06; 95% CI 1.00; 1.12) both differentiated between NSSI and suicide attempt, while the PGS for other phenotypes did not. The LRT between the multivariable and base models was significant (Chi square = 11.38, df = 2, p = 0.003), and the multivariable model explained a larger proportion of variance (Nagelkerke's pseudo-R 2  = 0.028 vs. 0.025). While NSSI and suicidal behavior are similarly genetically related to a range of mental health and related outcomes, genetic liability to anorexia nervosa and suicidal behavior is higher among those reporting a suicide attempt than those reporting NSSI-only. Further elucidation of these distinctions is necessary, which will require a nuanced assessment of suicidal versus non-suicidal self-injury in large samples.
      (© 2024 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.)
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    • Grant Information:
      United Kingdom WT_ Wellcome Trust; P50 AA022537 United States AA NIAAA NIH HHS; R01 MH125938 United States MH NIMH NIH HHS; Brain and Behavior Research Foundation; United States AA NIAAA NIH HHS; United States MH NIMH NIH HHS; American Foundation for Suicide Prevention
    • Contributed Indexing:
      Keywords: non‐suicidal self‐injury; polygenic score; psychopathology; suicide attempt
    • Publication Date:
      Date Created: 20240329 Date Completed: 20241114 Latest Revision: 20241117
    • Publication Date:
      20241118
    • Accession Number:
      PMC11438949
    • Accession Number:
      10.1002/ajmg.b.32982
    • Accession Number:
      38551161