Gene networks and systems biology in Alzheimer's disease: Insights from multi-omics approaches.

Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Ltd.
Original Publication: Orlando, FL : Elsevier, Inc.

Alzheimer Disease*/genetics ; Systems Biology* ; Gene Regulatory Networks*/genetics; Humans ; Epigenomics ; Genomics ; Brain/metabolism ; Multiomics

Despite numerous studies in the field of dementia and Alzheimer's disease (AD), a comprehensive understanding of this devastating disease remains elusive. Bulk transcriptomics have provided insights into the underlying genetic factors at a high level. Subsequent technological advancements have focused on single-cell omics, encompassing techniques such as single-cell RNA sequencing and epigenomics, enabling the capture of RNA transcripts and chromatin states at a single cell or nucleus resolution. Furthermore, the emergence of spatial omics has allowed the study of gene responses in the vicinity of amyloid beta plaques or across various brain regions. With the vast amount of data generated, utilizing gene regulatory networks to comprehensively study this disease has become essential. This review delves into some techniques employed in the field of AD, explores the discoveries made using these techniques, and provides insights into the future of the field.
(© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

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1RF1AG071683 National Institutes on Aging; U54 AG054349 United States AG NIA NIH HHS; R01 NS128523 United States NS NINDS NIH HHS; R01NS128523 National Institute of Health; U54 AG054349-06 National Institutes on Aging; T32 GM136624 United States GM NIGMS NIH HHS; Adelson Medical Research Foundation funds; RF1 AG071683 United States AG NIA NIH HHS; 1T32GM136624-01 National Institute of Health (NIH) Institutional National Research Service Award

Keywords: Alzheimer's disease; epigenomics; genetics; multi‐omics; single‐nucleus RNA‐seq; spatial; spatial transcriptomics; transcriptomics

Date Created: 20240327 Date Completed: 20240515 Latest Revision: 20240716

20240717

PMC11095483

10.1002/alz.13790

38534018