Effects of tooth loss on behavioral and psychological symptoms of dementia in app knock-in mice.

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  • Additional Information
    • Source:
      Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101226721 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1880-3865 (Electronic) Linking ISSN: 13490079 NLM ISO Abbreviation: J Oral Biosci Subsets: MEDLINE
    • Publication Information:
      Publication: 2012- : Amsterdam : Elsevier B.V.
      Original Publication: Tokyo : Japanese Association for Oral Biology, [2004]-
    • Subject Terms:
      Mice, Inbred C57BL* ; Tooth Loss*/genetics ; Tooth Loss*/psychology ; Aggression*/psychology ; Aggression*/physiology; Animals ; Mice ; Behavior, Animal ; Disease Models, Animal ; Dementia/genetics ; Dementia/psychology ; Mice, Transgenic ; Male ; Alzheimer Disease/genetics ; Alzheimer Disease/psychology ; Alzheimer Disease/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism
    • Abstract:
      Objectives: Many patients with Alzheimer's disease (AD) experience behavioral and psychological symptoms of dementia (BPSD), which significantly affect their quality of life. It is known that 5-Hydroxytryptamine (5-HT) plays a crucial role in the development of BPSD. While the relationship between tooth loss and AD symptoms has been acknowledged, the aspect of aggression has not been focused on until now. Despite the established importance of 5-HT in BPSD, how tooth loss is related to the exacerbation of AD symptoms, especially in terms of aggression, remains largely unexplored. Although nutritional status is known to influence the progression of dementia, the specific effect of tooth loss on peripheral symptoms, notably aggression, is not well understood.
      Methods: In our study, we conducted maxillary molar extractions in aged C57BL/6J and App NL-G-F mice and observed their condition over a 3-month period. During this time, we documented significant behavioral and genetic differences between mice in the control groups and mice that underwent tooth extraction. Notably, mice that underwent tooth extraction exhibited a considerable decline in cognitive function and increased in aggression 3 months after tooth extraction compared with the control groups (C57BL/6J and App NL-G-F mice).
      Results: Our findings suggest that molar loss may lead to reduced 5-HT levels in the hippocampus, possibly mediated by the trigeminal nerve, contributing to the development of aggression and BPSD in AD.
      Conclusion: This study sheds light on the intricate relationships between oral health, 5-HT, and AD symptoms, offering valuable insights into potential therapeutic avenues for managing BPSD in patients with dementia.
      Competing Interests: Declaration of competing interest All authors are required to disclose any COI within the period of 12 months prior to the submission of any manuscript in the subject matter of which any company, entity, or organization has an interest.
      (Copyright © 2024 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Aggression; App(NL-G-F); BPSD; Mastication; Tooth loss
    • Accession Number:
      0 (Amyloid beta-Protein Precursor)
    • Publication Date:
      Date Created: 20240323 Date Completed: 20240613 Latest Revision: 20240627
    • Publication Date:
      20240627
    • Accession Number:
      10.1016/j.job.2024.03.005
    • Accession Number:
      38521152