Menu
×
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
2 p.m. – 6 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
2 p.m. – 6 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Metformin and other anti-diabetic medication use and breast cancer incidence in the Nurses' Health Studies.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Wang T;Wang T;Wang T;Wang T; Chai B; Chai B; Chen WY; Chen WY; Chen WY; Holmes MD; Holmes MD; Holmes MD; Erdrich J; Erdrich J; Hu FB; Hu FB; Hu FB; Rosner BA; Rosner BA; Rosner BA; Tamimi RM; Tamimi RM; Willett WC; Willett WC; Kang JH; Kang JH; Eliassen AH; Eliassen AH; Eliassen AH; Eliassen AH
- Source:
International journal of cancer [Int J Cancer] 2024 Jul 15; Vol. 155 (2), pp. 211-225. Date of Electronic Publication: 2024 Mar 22.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
- Publication Information: Publication: 1995- : New York, NY : Wiley-Liss
Original Publication: 1966-1984 : Genève : International Union Against Cancer - Subject Terms: Metformin*/therapeutic use ; Breast Neoplasms*/epidemiology ; Breast Neoplasms*/drug therapy ; Hypoglycemic Agents*/therapeutic use ; Diabetes Mellitus, Type 2*/drug therapy ; Diabetes Mellitus, Type 2*/epidemiology; Humans ; Female ; Incidence ; Middle Aged ; Adult ; Prospective Studies ; United States/epidemiology ; Risk Factors ; Nurses/statistics & numerical data ; Proportional Hazards Models
- Abstract: We aimed to examine the association between the use of metformin and other anti-diabetic medications and breast cancer incidence within two large prospective cohort studies. We followed 185,181 women who participated in the Nurses' Health Study (NHS; 1994-2016) and the NHSII (1995-2017), with baseline corresponding to the date metformin was approved for type 2 diabetes (T2D) treatment in the US Information on T2D diagnosis, anti-diabetes medications, and other covariates was self-reported at baseline and repeatedly assessed by follow-up questionnaires every 2 years. Breast cancer cases were self-reported and confirmed by medical record review. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between medication use and breast cancer were estimated using Cox proportional hazards regression models, adjusting for breast cancer risk factors. During 3,324,881 person-years of follow-up, we ascertained 9,192 incident invasive breast cancer cases, of which 451 were among women with T2D. Compared with women without T2D (n = 169,263), neither metformin use (HR = 0.97; 95% CI = 0.81-1.15) nor other anti-diabetic medications use (HR = 1.11; 95% CI = 0.90-1.36) associated with significantly lower breast cancer incidence. Among women with T2D (n = 15,918), compared with metformin never users, metformin ever use was not significantly inversely associated with breast cancer (HR = 0.92; 95% CI = 0.74-1.15). Although we observed that past use of metformin was inversely associated with breast cancer in the T2D population (HR = 0.67; 95% CI = 0.48-0.94), current use (HR = 1.01; 95% CI = 0.80-1.27) and longer duration of metformin use were not associated with breast cancer (each 2-year interval: HR = 1.01; 95% CI = 0.95-1.07). Overall, metformin use was not associated with the risk of developing breast cancer among the overall cohort population or among women with T2D.
(© 2024 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.) - References: Breast Cancer Res. 2023 Aug 30;25(1):101. (PMID: 37649039)
Lancet. 1991 Sep 28;338(8770):774-8. (PMID: 1681160)
Pharmaceuticals (Basel). 2022 May 19;15(5):. (PMID: 35631452)
Breast Cancer Res. 2008;10(4):R67. (PMID: 18681955)
Epidemiology. 2017 May;28(3):446-454. (PMID: 28166101)
Pharmacoepidemiol Drug Saf. 2015 Aug;24(8):865-74. (PMID: 26132313)
Diabetes Care. 2012 Dec;35(12):2665-73. (PMID: 23173135)
Int J Cancer. 2016 Apr 15;138(8):1915-27. (PMID: 26616262)
BMJ Open Diabetes Res Care. 2015 Jan 24;3(1):e000049. (PMID: 25664181)
Exp Diabetes Res. 2012;2012:413782. (PMID: 22719752)
Anticancer Res. 2021 Dec;41(12):5913-5918. (PMID: 34848445)
Am J Epidemiol. 2009 Dec 1;170(11):1422-32. (PMID: 19875646)
Eur J Epidemiol. 2020 Sep;35(9):807-819. (PMID: 32728914)
Ther Clin Risk Manag. 2015 Aug 28;11:1315-23. (PMID: 26357479)
Cancer Causes Control. 2016 May;27(5):709-20. (PMID: 27053250)
J Clin Oncol. 2012 Aug 10;30(23):2844-52. (PMID: 22689798)
Epidemiology. 2023 Sep 1;34(5):690-699. (PMID: 37227368)
Am J Clin Nutr. 2005 Sep;82(3):675-84; quiz 714-5. (PMID: 16155283)
Br J Cancer. 2012 Oct 23;107(9):1608-17. (PMID: 22996614)
J Clin Oncol. 2023 Dec 10;41(35):5356-5362. (PMID: 37695982)
Int J Epidemiol. 2017 Apr 1;46(2):728-744. (PMID: 28031313)
J Breast Cancer. 2015 Sep;18(3):264-70. (PMID: 26472977)
Diabetes Care. 2003 Jun;26(6):1847-51. (PMID: 12766121)
Diabetes Care. 2022 Jan 1;45(Suppl 1):S8-S16. (PMID: 34964872)
Diabetes Care. 2010 Jun;33(6):1304-8. (PMID: 20299480)
Cancer Epidemiol Biomarkers Prev. 2019 Nov;28(11):1802-1808. (PMID: 31395589)
JAMA. 2022 May 24;327(20):1963-1973. (PMID: 35608580)
Diabetes Care. 2014 Sep;37(9):2522-32. (PMID: 24898303)
J Clin Oncol. 2009 Jul 10;27(20):3271-3. (PMID: 19487373)
Cancer Med. 2023 May;12(10):11703-11718. (PMID: 36533539)
Arch Intern Med. 2009 Jan 26;169(2):115-21; discussion 121. (PMID: 19171806)
Diabetes Care. 2009 Sep;32(9):1620-5. (PMID: 19564453)
Int J Epidemiol. 2019 Apr 1;48(2):527-537. (PMID: 30753459)
Nat Rev Cancer. 2005 May;5(5):388-96. (PMID: 15864280)
Diabetes Care. 2012 Jan;35(1):119-24. (PMID: 22100960)
J Natl Cancer Inst. 1998 Aug 5;90(15):1155-60. (PMID: 9701365)
Diabetologia. 2017 Sep;60(9):1566-1576. (PMID: 28776081)
Cancer Epidemiol Biomarkers Prev. 2018 Jun;27(6):627-635. (PMID: 29618465)
Breast Cancer Res Treat. 2022 Oct;195(3):421-430. (PMID: 35969285)
Cancer Epidemiol Biomarkers Prev. 2021 Oct;30(10):1921-1931. (PMID: 34289970)
Diabetes. 1979 Dec;28(12):1039-57. (PMID: 510803)
J Clin Oncol. 2012 Oct 1;30(28):3468-77. (PMID: 22927520)
Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):101-11. (PMID: 21119073)
Diabetologia. 2009 Sep;52(9):1766-77. (PMID: 19572116)
Ann Oncol. 2021 Mar;32(3):351-359. (PMID: 33516778)
Curr Oncol. 2017 Apr;24(2):e85-e91. (PMID: 28490930)
Breast Cancer Res Treat. 2014 Jun;145(3):785-90. (PMID: 24816805) - Grant Information: R01 CA050385 United States CA NCI NIH HHS; R01 ES028033 United States ES NIEHS NIH HHS; P01 CA087969 United States CA NCI NIH HHS; R00 CA267557 United States CA NCI NIH HHS; UM1 CA186107 United States CA NCI NIH HHS; T32 CA009001 United States CA NCI NIH HHS; UM1CA186107 United States CA NCI NIH HHS; U01CA176726 United States CA NCI NIH HHS; P01CA87969 United States CA NCI NIH HHS; K99 CA267557 United States CA NCI NIH HHS; R01CA050385 United States CA NCI NIH HHS; R01ES028033 United States ES NIEHS NIH HHS; R00CA267557 United States CA NCI NIH HHS; K99CA267557 United States CA NCI NIH HHS; U01 CA176726 United States CA NCI NIH HHS; Breast Cancer Research Foundation; T32CA009001 United States CA NCI NIH HHS
- Contributed Indexing: Keywords: breast cancer; diabetes mellitus; metformin
- Publication Date: Date Created: 20240323 Date Completed: 20240515 Latest Revision: 20240517
- Publication Date: 20240517
- Accession Number: PMC11096056
- Accession Number: 10.1002/ijc.34917
- Accession Number: 38520039
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.