GO/AgNW aided sustained release of ciprofloxacin loaded in Starch/PVA nanocomposite mats for wound dressings application.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Guildford, Eng., IPC Science and Technology Press.
    • Subject Terms:
      Ciprofloxacin*/chemistry ; Ciprofloxacin*/pharmacology ; Ciprofloxacin*/administration & dosage ; Nanocomposites*/chemistry ; Starch*/chemistry ; Polyvinyl Alcohol*/chemistry ; Bandages* ; Graphite*/chemistry ; Silver*/chemistry ; Anti-Bacterial Agents*/pharmacology ; Anti-Bacterial Agents*/chemistry ; Delayed-Action Preparations*; Drug Liberation ; Staphylococcus aureus/drug effects ; Escherichia coli/drug effects ; Nanowires/chemistry ; Wound Healing/drug effects ; Nanofibers/chemistry ; Humans ; Microbial Sensitivity Tests ; Drug Carriers/chemistry
    • Abstract:
      Compared to conventional bandages, which do not meet all wound care requirements, nanofiber wound dressings could provide a potentially excellent environment for healing. In the present research, nanocomposite membrane based on starch (St) - polyvinyl alcohol (PVA) nanofibers containing ciprofloxacin antibiotic drug loaded on graphene oxide‑silver nanowire (GO-AgNWs) hybrid nanoparticles is produced by electrospinning process. Morphological studies showed that the length and diameter of silver nanowires are 21 ± 9.17 μm and 82 ± 10.52 nm, respectively. The contact angle of 57.1° due to the hydrophilic nature of nanofibers, also the swelling degree of 679.51 % and, the water vapor permeability of 2627 ± 56 (g/m 2 .day) can be expressed as a confirmation of the ability of this wound dressing to manage secretions around the wound. In evaluating the antibacterial activity of these nanocomposite membranes against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria, the most potent antibacterial effect is in the case of nanofibers containing a high percentage of starch and nanoparticles carrying ciprofloxacin; with non-growth halos of 47.58 mm and 22.06 mm was recorded. The release of ciprofloxacin drug in vitro was reported to be 61.69 % during 24 h, and the final release rate was 82.17 %. Despite the biocompatibility and cell viability of 97.74 % and the biodegradability rate of 28.51 %, the StP-GOAgNWCip nanocomposite membrane can be introduced as a suitable candidate for wound dressing.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Ciprofloxacin; Drug delivery; Graphene oxide; Silver nanowire; Starch; Wound dressing
    • Accession Number:
      5E8K9I0O4U (Ciprofloxacin)
      9005-25-8 (Starch)
      9002-89-5 (Polyvinyl Alcohol)
      7782-42-5 (Graphite)
      3M4G523W1G (Silver)
      0 (graphene oxide)
      0 (Anti-Bacterial Agents)
      0 (Delayed-Action Preparations)
      0 (Drug Carriers)
    • Publication Date:
      Date Created: 20240321 Date Completed: 20240430 Latest Revision: 20240430
    • Publication Date:
      20240430
    • Accession Number:
      10.1016/j.ijbiomac.2024.130977
    • Accession Number:
      38513893