Celiac disease in children and adolescents with Down syndrome: behavioural, adaptive and sleep profiles.

Publisher: Blackwell Scientific Publications on behalf of the Royal Society for Mentally Handicapped Children and Adults Country of Publication: England NLM ID: 9206090 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2788 (Electronic) Linking ISSN: 09642633 NLM ISO Abbreviation: J Intellect Disabil Res Subsets: MEDLINE

Original Publication: Oxford, UK : Blackwell Scientific Publications on behalf of the Royal Society for Mentally Handicapped Children and Adults, 1992-

Down Syndrome*/physiopathology ; Down Syndrome*/complications ; Celiac Disease*/complications ; Celiac Disease*/physiopathology ; Sleep Wake Disorders*/physiopathology ; Sleep Wake Disorders*/epidemiology ; Adaptation, Psychological*/physiology ; Problem Behavior* ; Comorbidity*; Humans ; Adolescent ; Male ; Female ; Child ; Child, Preschool ; Retrospective Studies

Background: Individuals with Down syndrome (DS) exhibit higher risk for celiac disease (CD) than general population. Although literature suggests CD could be associated with behavioural problems in both paediatric and adult age, such association has been poorly explored in children and adolescents DS. Therefore, the current study aimed to investigate differences in emotional/behavioural difficulties, adaptive skills and sleep problems between children with DS with and without CD.
Methods: Data were retrospectively collected from a database including data from 381 individuals with DS (3-18 years). The final sample included 65 participants, 27 with co-occurring CD and 38 age, IQ, sex and body mass index-matched controls without CD. Emotional/behavioural difficulties, adaptive skills and sleep problems were assessed through parent report questionnaires.
Results: No group differences emerged in emotional/behavioural difficulties, whereas participants in the CD group showed better adaptive skills in the practical domain than control group. Weak differences emerged in sleep problems.
Conclusions: Youth with DS and co-occurring CD do not exhibit more emotional and behavioural problems than youth with DS without co-occurring CD but exhibit better adaptive skills in the practical domain.
(© 2024 The Authors. Journal of Intellectual Disability Research published by John Wiley & Sons and MENCAP.)

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Italian Ministry of Health

Date Created: 20240321 Date Completed: 20240730 Latest Revision: 20240730

20240730

10.1111/jir.13135

38509762