Classification of type 1 diabetes: A pathogenic and treatment-based classification.

Publisher: Elsevier Ltd Country of Publication: Netherlands NLM ID: 101462250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0334 (Electronic) Linking ISSN: 18714021 NLM ISO Abbreviation: Diabetes Metab Syndr Subsets: MEDLINE

Original Publication: Amsterdam : Elsevier Ltd.

Diabetes Mellitus, Type 1*/diagnosis ; Diabetes Mellitus, Type 1*/classification ; Diabetes Mellitus, Type 1*/immunology ; Diabetes Mellitus, Type 1*/therapy ; Autoantibodies*/immunology ; Autoantibodies*/blood; Humans ; C-Peptide/blood

Aim: To improve the diagnosis and classification of patients who fail to satisfy current type 1 diabetes diagnostic criteria.
Methods: Review of the literature and current diagnostic guidelines.
Discussion: We propose a novel, clinically useful classification based on islet autoantibody status and non-fasting C-peptide levels. Notably, we discuss the subgroup of latent autoimmune diabetes in the young and propose a new subgroup classification of autoantibody negative type 1 diabetes in remission.
Conclusion: A novel classification system is proposed. Further work is needed to accurately diagnose and manage minority type 1 diabetes subgroups.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved.)

Keywords: Atypical diabetes; Autoantibody negative type 1 diabetes; Diabetes classification; Misclassification

Date Created: 20240319 Date Completed: 20240520 Latest Revision: 20240520

20240521

10.1016/j.dsx.2024.102986

38503115