Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer.

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  • Author(s): Zhu Z;Zhu Z; Peng Q; Peng Q; Duan X; Duan X; Li J; Li J; Li J
  • Source:
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2024 Apr; Vol. 44 (4), pp. 158-169. Date of Electronic Publication: 2024 Mar 18.
  • Publication Type:
    Review; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 9507088 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7465 (Electronic) Linking ISSN: 10799907 NLM ISO Abbreviation: J Interferon Cytokine Res Subsets: MEDLINE
    • Publication Information:
      Publication: Larchmont, NY : Mary Ann Liebert
      Original Publication: New York, NY : Mary Ann Liebert, c1995-
    • Subject Terms:
      Colorectal Neoplasms*/therapy ; Interleukin-12*/immunology ; Interleukin-12*/therapeutic use; Humans ; Cytokines ; Interleukin-12 Subunit p35 ; Interleukin-12 Subunit p40 ; Interleukin-23
    • Abstract:
      Interleukin 12 (IL-12) is a heterodimer consisting of 2 subunits, p35 and p40, with unique associations and interacting functions with its family members. IL-12 is one of the most important cytokines regulating the immune system response and is integral to adaptive immunity. IL-12 has shown marked therapeutic potential in a variety of tumor types. This review therefore summarizes the characteristics of IL-12 and its application in tumor treatment, focusing on its antitumor effects in colorectal cancer (CRC) and potential radiosensitization mechanisms. We aim to provide a current reference for IL-12 and other potential CRC treatment strategies.
    • Contributed Indexing:
      Keywords: IL-12; antitumor therapy; colorectal cancer; immunotherapy
    • Accession Number:
      0 (Cytokines)
      187348-17-0 (Interleukin-12)
      0 (Interleukin-12 Subunit p35)
      0 (Interleukin-12 Subunit p40)
      0 (Interleukin-23)
    • Publication Date:
      Date Created: 20240318 Date Completed: 20240408 Latest Revision: 20241114
    • Publication Date:
      20241114
    • Accession Number:
      10.1089/jir.2023.0190
    • Accession Number:
      38498032