Minimal effect of long-term clonazepam on cognitive function in patients with isolated rapid eye movement sleep behavior disorder.

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  • Additional Information
    • Source:
      Publisher: American Academy of Sleep Medicine Country of Publication: United States NLM ID: 101231977 Publication Model: Print Cited Medium: Internet ISSN: 1550-9397 (Electronic) Linking ISSN: 15509389 NLM ISO Abbreviation: J Clin Sleep Med Subsets: MEDLINE
    • Publication Information:
      Original Publication: Darien, IL : American Academy of Sleep Medicine, 2005-
    • Subject Terms:
      Clonazepam*/therapeutic use ; REM Sleep Behavior Disorder*/drug therapy ; REM Sleep Behavior Disorder*/physiopathology ; Cognition*/drug effects; Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Neuropsychological Tests/statistics & numerical data ; Cognitive Dysfunction/etiology
    • Abstract:
      Study Objectives: Despite its widespread use in patients with isolated rapid eye movement sleep behavior disorder (iRBD), the cognitive effect of clonazepam is uncertain. This study aimed to investigate the effect of cumulative clonazepam on cognitive function in patients with iRBD.
      Methods: Demographic characteristics, baseline cognitive test, and most recent cognitive test information were collected retrospectively. Based on cumulative clonazepam doses, patients were classified into 4 subgroups: group 1, < 365 mg (1 mg × 1 year); group 2, 365 mg to < 1,095 mg (1 mg × 3 years); group 3, 1,095 mg to < 2,190 mg (1 mg × 6 years); and group 4, 2,190 mg or more. Cognitive test scores were calculated as z scores adjusted for age, education, and sex.
      Results: This study included 101 patients with iRBD (63 males). Groups 1, 2, 3, and 4 had 14, 20, 32, and 35 patients, respectively. In within-group comparisons, follow-up Digit Span Backward test and the Trail Making Test A scores decreased in group 3, and follow-up Trail Making Test A and the Trail Making Test B scores decreased significantly in group 4. In the multiple regression analysis to determine influential factors on cognitive decline, cumulative clonazepam dose did not show a significant correlation with any cognitive domain. Follow-up cognitive function showed significant correlation only with baseline cognitive function.
      Conclusions: Memory and executive functions tended to decline in patients with iRBD. However, there was no significant effect of cumulative clonazepam. There was no evidence that long-term use of clonazepam was related to cognitive decline in patients with iRBD.
      Citation: Lee M, Kim TK, Hong JK, Yoon I-Y. Minimal effect of long-term clonazepam on cognitive function in patients with isolated rapid eye movement sleep behavior disorder. J Clin Sleep Med . 2024;20(7):1173-1182.
      (© 2024 American Academy of Sleep Medicine.)
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    • Contributed Indexing:
      Keywords: REM sleep behavior disorder; clonazepam; cognitive decline; executive function; memory
    • Accession Number:
      5PE9FDE8GB (Clonazepam)
    • Publication Date:
      Date Created: 20240318 Date Completed: 20240702 Latest Revision: 20240704
    • Publication Date:
      20240704
    • Accession Number:
      PMC11217636
    • Accession Number:
      10.5664/jcsm.11126
    • Accession Number:
      38494993