Description of a national, multi-center registry of patients with sickle cell disease and SARS-CoV-2 infection: Data from the Pediatric COVID-19 United States Registry.

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  • Additional Information
    • Corporate Authors:
      Pediatric COVID‐19 US Registry
    • Source:
      Publisher: John Wiley Country of Publication: United States NLM ID: 101186624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-5017 (Electronic) Linking ISSN: 15455009 NLM ISO Abbreviation: Pediatr Blood Cancer Subsets: MEDLINE
    • Publication Information:
      Original Publication: Hoboken, N.J. : John Wiley, c 2004-
    • Subject Terms:
      COVID-19*/*complications; Anemia, Sickle Cell*/complications ; Anemia, Sickle Cell*/epidemiology ; Anemia, Sickle Cell*/therapy ; COVID-19*/epidemiology ; Registries* ; SARS-CoV-2*; Humans ; Child ; Female ; Male ; Adolescent ; United States/epidemiology ; Child, Preschool ; Infant ; Systemic Inflammatory Response Syndrome/epidemiology ; Systemic Inflammatory Response Syndrome/etiology ; Hospitalization/statistics & numerical data
    • Abstract:
      Children with sickle cell disease (SCD) are at risk of complications from viral infections, including SARS-CoV-2. We present the clinical characteristics and outcomes of pediatric patients with SCD from the Pediatric COVID-19 United States Registry who developed acute COVID-19 due to SARS-CoV-2 infection (n = 259) or multisystem inflammatory syndrome in children (MIS-C; n = 4). Nearly half of hospitalized children with SCD and SARS-CoV-2 infection required supplemental oxygen, though children with SCD had fewer intensive care (ICU) admissions compared to the general pediatric and immunocompromised populations. All registry patients with both SCD and MIS-C required ICU admission. Children with SCD are at risk of severe disease with SARS-CoV-2 infection, highlighting the importance of vaccination in this vulnerable population.
      (© 2024 Wiley Periodicals LLC.)
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    • Grant Information:
      T32 HL007150 United States HL NHLBI NIH HHS
    • Contributed Indexing:
      Investigator: MI Ardura, Nationwide Children's Hospital and The Ohio State University.; S Arnold, Le Bonheur Children's Hospital.; D Celentano, Good Samaritan University Hospital.; H Custodio, University of South Alabama Children's and Women's Hospital.; L Danziger-Isakov, Cincinnati Children's Hospital Medical Center and University of Cincinnati.; L Enane, Riley Hospital for Children.; C Foster, Texas Children's Hospital.; D Furstenau, Johns Hopkins University School of Medicine.; CG Carreno, Medical City Children's Hospital.; S Guerguis, Children's Hospital at Montefiore.; EA Hammershaimb, University of Maryland Medical Center and University of Maryland School of Medicine.; E Harrison, Children's Minnesota.; J Mannheim, Rush University Medical Center.; B Mehta, University of Illinois College of Medicine, Peoria, IL, Children's Hospital of Illinois at OSF Medical Center.; K Mongkolrattanothai, Children's Hospital Los Angeles.; M Murray, Advocate Children's Hospital.; MM Nakamura, Boston Children's Hospital and Harvard Medical School.; M Rathore, University of Florida Center for HIV/AIDS Research, Education and Service (UF CARES)/Wolfson Children's Hospital.; M Reyna, Ann & Robert H. Lurie Children's Hospital of Chicago.; RP Santos, Children's of Mississippi, University of Mississippi Medical Center.; L Sass, Children's Hospital of The King's Daughters.; HA Shihan, Children's Hospital of Michigan.; MJ Smith, Duke University Medical Center.; VA Statler, Norton Children's and University of Louisville School of Medicine.; MS Whitworth, Cook Children's Medical Center.; A Yarbrough, Children's of Alabama.; FH Zhu, Children's Wisconsin.
      Keywords: COVID; MIS‐C; SCD; sickle cell anemia
    • Subject Terms:
      pediatric multisystem inflammatory disease, COVID-19 related
    • Publication Date:
      Date Created: 20240312 Date Completed: 20240424 Latest Revision: 20240509
    • Publication Date:
      20240510
    • Accession Number:
      PMC11039375
    • Accession Number:
      10.1002/pbc.30909
    • Accession Number:
      38469996