Unmet needs in biomarkers for autoimmune pancreatitis diagnosis.

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  • Author(s): Wang BC;Wang BC; Fan JG; Fan JG
  • Source:
    World journal of gastroenterology [World J Gastroenterol] 2024 Feb 14; Vol. 30 (6), pp. 523-526.
  • Publication Type:
    Editorial
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE
    • Publication Information:
      Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group
      Original Publication: Beijing : WJG Press, c1998-
    • Subject Terms:
      Autoimmune Pancreatitis*/diagnosis ; Autoimmune Diseases*; Humans ; Diagnosis, Differential ; Biomarkers ; Chronic Disease ; Immunoglobulin G
    • Abstract:
      Autoimmune pancreatitis (AIP) is a rare chronic autoimmune disorder. The diagnosis of AIP mainly depends on histopathology, imaging and response to treatment. Serum immunoglobulin 4 (IgG4) is used only as collateral evidence in diagnostic criteria for AIP because of its moderate sensitivity. Serum IgG4 levels are normal in 15%-37% of type 1 AIP and most of type 2 AIP patients. In these patients, the indeterminate imaging and histopathology may lead to the difficulty in definitive diagnosis of AIP. Therefore, discovery of new biomarkers is important for AIP diagnosis. Here, we provide some views on the progression and challenges in identifying novel serological biomarkers in AIP diagnosis.
      Competing Interests: Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
      (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
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    • Contributed Indexing:
      Keywords: Autoantibody; Autoimmune pancreatitis; Biomarker, Cytokine; Immunoglobulin G4
    • Accession Number:
      0 (Biomarkers)
      0 (Immunoglobulin G)
    • Publication Date:
      Date Created: 20240311 Date Completed: 20240312 Latest Revision: 20240312
    • Publication Date:
      20240312
    • Accession Number:
      PMC10921148
    • Accession Number:
      10.3748/wjg.v30.i6.523
    • Accession Number:
      38463027