MCSdb, a database of proteins residing in membrane contact sites.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101640192 Publication Model: Electronic Cited Medium: Internet ISSN: 2052-4463 (Electronic) Linking ISSN: 20524463 NLM ISO Abbreviation: Sci Data Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, 2014-
    • Subject Terms:
      Organelles*/chemistry ; Cell Membrane*/chemistry ; Proteins*/chemistry ; Databases, Protein*
    • Abstract:
      Organelles do not act as autonomous discrete units but rather as interconnected hubs that engage in extensive communication by forming close contacts called "membrane contact sites (MCSs)". And many proteins have been identified as residing in MCS and playing important roles in maintaining and fulfilling specific functions within these microdomains. However, a comprehensive compilation of these MCS proteins is still lacking. Therefore, we developed MCSdb, a manually curated resource of MCS proteins and complexes from publications. MCSdb documents 7010 MCS protein entries and 263 complexes, involving 24 organelles and 44 MCSs across 11 species. Additionally, MCSdb orchestrates all data into different categories with multitudinous information for presenting MCS proteins. In summary, MCSdb provides a valuable resource for accelerating MCS functional interpretation and interorganelle communication deciphering.
      (© 2024. The Author(s).)
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    • Accession Number:
      0 (Proteins)
    • Publication Date:
      Date Created: 20240308 Date Completed: 20240311 Latest Revision: 20240312
    • Publication Date:
      20240312
    • Accession Number:
      PMC10923927
    • Accession Number:
      10.1038/s41597-024-03104-7
    • Accession Number:
      38459036