A novel radiomics nomogram based on T2-sampling perfection with application-optimized contrasts using different flip-angle evolutions (SPACE) images for predicting cochlear and vestibular endolymphatic hydrops in Meniere's disease patients.

Publisher: Springer International Country of Publication: Germany NLM ID: 9114774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1084 (Electronic) Linking ISSN: 09387994 NLM ISO Abbreviation: Eur Radiol Subsets: MEDLINE

Original Publication: Berlin : Springer International, c1991-

Meniere Disease*/diagnostic imaging ; Meniere Disease*/complications ; Nomograms* ; Magnetic Resonance Imaging*/methods ; Endolymphatic Hydrops*/diagnostic imaging; Humans ; Male ; Female ; Middle Aged ; Adult ; Aged ; Cochlea/diagnostic imaging ; Young Adult ; Radiomics

Objectives: To construct and validate a radiomics nomogram based on T2-sampling perfection with application-optimized contrasts using different flip-angle evolutions (SPACE) images for predicting cochlear and vestibular endolymphatic hydrops (EH) in Meniere's disease patients.
Methods: A total of 156 patients (312 affected ears) with bilateral definite Meniere's disease who underwent delayed enhancement MRI scans were enrolled in this study. All ears of the patients were divided into a training set (n = 218) and an internal validation set (n = 94). A radiomics nomogram was constructed from radiomics features extracted from the T2-SPACE images, and a radiomics score was calculated. Performance of the radiomics nomogram was assessed using receiver operating characteristics analysis.
Results: Five features were selected for the construction of the cochlear radiomics nomogram, and seven features for the vestibular radiomics nomogram. The radiomics nomograms exhibited robust performance in differentiating between EH-positive and EH-negative statuses in both training and validation cohorts, with the area under the receiver operating characteristics curve values for cochlear and vestibular radiomic nomograms being 0.703 and 0.728 in the training set, and 0.718 and 0.701 in the validation set, respectively.
Conclusion: The novel radiomics nomograms based on T2-SPACE images were successfully constructed to predict cochlear and vestibular EH in Meniere's disease. The models showed a solid and superior performance and may play an important role in the EH prediction.
Clinical Relevance Statement: We constructed a novel radiomics nomogram, which can be a very useful tool for predicting cochlear and vestibular endolymphatic hydrops in Meniere's disease patients.
Key Points: • This is the first T2-SPACE-based nomogram to predict cochlear and vestibular endolymphatic hydrops. • The nomogram is of great value to patients who are unable to undergo delayed enhancement MRI scans.
(© 2024. The Author(s), under exclusive licence to European Society of Radiology.)

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19411965700 Shanghai Municipal Science and Technology Commission Biomedicine Division Western Medicine Guidance Project

Keywords: Endolymphatic hydrops; Magnetic resonance imaging; Meniere’s disease; Radiomics; T2-SPACE

Date Created: 20240308 Date Completed: 20240830 Latest Revision: 20240831

20240831

10.1007/s00330-024-10670-2

38457037