Pink1 balances reticulophagy and mitophagy by regulating distinct E3 ubiquitin ligases.

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  • Author(s): Yin Z;Yin Z;Yin Z; Klionsky DJ; Klionsky DJ
  • Source:
    Autophagy [Autophagy] 2024 May; Vol. 20 (5), pp. 983-984. Date of Electronic Publication: 2024 Mar 08.
  • Publication Type:
    Journal Article; Editorial
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: MEDLINE
    • Publication Information:
      Publication: 2015- : Philadelphia, PA : Taylor & Francis
      Original Publication: Georgetown, TX : Landes Bioscience, 2005-
    • Subject Terms:
      Ubiquitin-Protein Ligases*/metabolism ; Mitophagy*/physiology; Animals ; Humans ; Drosophila Proteins/metabolism ; Drosophila Proteins/genetics ; Autophagy/physiology ; Protein Serine-Threonine Kinases/metabolism ; Mitochondria/metabolism ; Drosophila melanogaster/metabolism
    • Abstract:
      The selective clearance of unwanted, damaged or dangerous components by macroautophagy/autophagy is critical for maintaining cellular homeostasis in organisms from yeast to humans. In recent years, significant progress has been made in understanding how phagophores selectively sequester specific cargo. Nevertheless, a fundamental question remains: Can distinct selective autophagy programs simultaneously operate within the same cell? A recent study from the Baehrecke lab has unveiled a developmentally programmed Pink1-dependent reticulophagy process in the Drosophila intestine. Furthermore, this study demonstrated that autophagy differentially clears mitochondria and ER in the same cell under the regulation of Pink1 through different E3 ubiquitin ligases, highlighting the need for further exploration in understanding the complexity of autophagic substrate selection and crosstalk between diverse autophagy programs.
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    • Grant Information:
      R35 GM131919 United States GM NIGMS NIH HHS
    • Contributed Indexing:
      Keywords: Autophagy receptor; Keap1; Pink1; mitophagy; selective autophagy
    • Accession Number:
      EC 2.3.2.27 (Ubiquitin-Protein Ligases)
      0 (Drosophila Proteins)
      EC 2.7.11.1 (Protein Serine-Threonine Kinases)
      EC 2.7.11.1 (PINK1 protein, Drosophila)
    • Publication Date:
      Date Created: 20240308 Date Completed: 20240527 Latest Revision: 20240604
    • Publication Date:
      20240604
    • Accession Number:
      PMC11135839
    • Accession Number:
      10.1080/15548627.2024.2323294
    • Accession Number:
      38456640