Lipid droplets and cellular lipid flux.

Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE

Original Publication: London : Macmillan Magazines Ltd., [1999-

Lipid Droplets*/metabolism ; Lipid Metabolism*; Homeostasis ; Fatty Acids/metabolism

Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review the current understanding of the mechanisms of lipid droplet biogenesis and turnover, the transfer of lipids and metabolites at membrane contact sites, and the role of lipid droplets in regulating fatty acid flux in lipotoxicity and cell death.
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R01 DK128099 United States DK NIDDK NIH HHS; R01 GM112948 United States GM NIGMS NIH HHS; R01GM112948 U.S. Department of Health & Human Services | National Institutes of Health (NIH); R01DK128099 U.S. Department of Health & Human Services | National Institutes of Health (NIH)

0 (Fatty Acids)

Date Created: 20240307 Date Completed: 20240318 Latest Revision: 20240905

20240905

PMC11228001

10.1038/s41556-024-01364-4

38454048