Integrin restriction by miR-34 protects germline progenitors from cell death during aging.

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  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford, UK : Wiley-Blackwell
      Original Publication: Oxford, UK : Blackwell Pub., c2002-
    • Subject Terms:
      MicroRNAs*/metabolism ; MicroRNAs*/genetics ; Germ Cells*/metabolism ; Aging*/genetics ; Aging*/metabolism ; Integrins*/metabolism ; Cell Death* ; Stem Cells*/metabolism; Animals ; Male ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/genetics ; Testis/metabolism ; Signal Transduction ; Drosophila/metabolism
    • Abstract:
      During aging, regenerative tissues must dynamically balance the two opposing processes of proliferation and cell death. While many microRNAs are differentially expressed during aging, their roles as dynamic regulators of tissue regeneration have yet to be described. We show that in the highly regenerative Drosophila testis, miR-34 levels are significantly elevated during aging. miR-34 modulates germ cell death and protects the progenitor germ cells from accelerated aging. However, miR-34 is not expressed in the progenitors themselves but rather in neighboring cyst cells that kill the progenitors. Transcriptomics followed by functional analysis revealed that during aging, miR-34 modifies integrin signaling by limiting the levels of the heterodimeric integrin receptor αPS2 and βPS subunits. In addition, we found that in cyst cells, this heterodimer is essential for inducing phagoptosis and degradation of the progenitor germ cells. Together, these data suggest that the miR-34-integrin signaling axis acts as a sensor of progenitor germ cell death to extend progenitor functionality during aging.
      (© 2024 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.)
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    • Contributed Indexing:
      Keywords: drosophila; miR‐34; aging; integrin; micro‐RNAs; phagoptosis; spermatogenesis
    • Accession Number:
      0 (MicroRNAs)
      0 (Integrins)
    • Publication Date:
      Date Created: 20240307 Date Completed: 20240611 Latest Revision: 20240708
    • Publication Date:
      20240709
    • Accession Number:
      PMC11166360
    • Accession Number:
      10.1111/acel.14131
    • Accession Number:
      38450871