The role of long-lived plasma cells in viral clearance.

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  • Author(s): Zhang M;Zhang M; Li M; Li M; Ma J; Ma J
  • Source:
    Journal of biological dynamics [J Biol Dyn] 2024 Dec; Vol. 18 (1), pp. 2325523. Date of Electronic Publication: 2024 Mar 06.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 101299725 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1751-3766 (Electronic) Linking ISSN: 17513758 NLM ISO Abbreviation: J Biol Dyn Subsets: MEDLINE
    • Publication Information:
      Original Publication: Abingdon, Oxon, UK : Taylor & Francis, c2007-
    • Subject Terms:
      Plasma Cells* ; Coinfection*; Humans ; Models, Biological ; Basic Reproduction Number ; Viral Load
    • Abstract:
      The adaptive immune system has two types of plasma cells (PC), long-lived plasma cells (LLPC) and short-lived plasma cells (SLPC), that differ in their lifespan. In this paper, we propose that LLPC is crucial to the clearance of viral particles in addition to reducing the viral basic reproduction number in secondary infections. We use a sequence of within-host mathematical models to show that, CD8 T cells, SLPC and memory B cells cannot achieve full viral clearance, and the viral load will reach a low positive equilibrium level because of a continuous replenishment of target cells. However, the presence of LLPC is crucial for viral clearance.
    • Contributed Indexing:
      Keywords: 92C30; Viral clearance; adaptive immune system; basic reproduction number; secondary infection; within-host mathematical model
    • Publication Date:
      Date Created: 20240306 Date Completed: 20240307 Latest Revision: 20240307
    • Publication Date:
      20240307
    • Accession Number:
      10.1080/17513758.2024.2325523
    • Accession Number:
      38445631