Turmeric-Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing.

Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Original Publication: Weinheim : WILEY-VCH, [2014]-

Wound Healing*/drug effects ; Nanoparticles*/chemistry ; Curcuma*/chemistry ; Diabetes Mellitus, Experimental*; Animals ; Mice ; Disease Models, Animal ; Cell Proliferation/drug effects ; Gels ; Rats ; Fibroblasts/drug effects ; Fibroblasts/metabolism

Regulation of excessive inflammation and impaired cell proliferation is crucial for healing diabetic wounds. Although plant-to-mammalian regulation offers effective approaches for chronic wound management, the development of a potent plant-based therapeutic presents challenges. This study aims to validate the efficacy of turmeric-derived nanoparticles (TDNPs) loaded with natural bioactive compounds. TDNPs can alleviate oxidative stress, promote fibroblast proliferation and migration, and reprogram macrophage polarization. Restoration of the fibroblast-macrophage communication network by TDNPs stimulates cellular regeneration, in turn enhancing diabetic wound healing. To address diabetic wound management, TDNPs are loaded in an ultralight-weight, high swelling ratio, breathable aerogel (AG) constructed with cellulose nanofibers and sodium alginate backbones to obtain TDNPs@AG (TAG). TAG features wound shape-customized accessibility, water-adaptable tissue adhesiveness, and capacity for sustained release of TDNPs, exhibiting outstanding performance in facilitating in vivo diabetic wound healing. This study highlights the potential of TDNPs in regenerative medicine and their applicability as a promising solution for wound healing in clinical settings.
(© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.)

Cell Metab. 2012 Apr 4;15(4):451-65. (PMID: 22482728)
Adv Mater. 2023 Jun;35(24):e2207826. (PMID: 36592157)
N Engl J Med. 1999 Sep 2;341(10):738-46. (PMID: 10471461)
J Extracell Vesicles. 2015 Dec 31;4:30087. (PMID: 26725829)
Adv Sci (Weinh). 2023 Nov;10(31):e2304243. (PMID: 37661933)
Int Wound J. 2016 Oct;13(5):892-903. (PMID: 25601358)
Adv Sci (Weinh). 2023 Aug;10(23):e2204681. (PMID: 37217831)
Sci Transl Med. 2021 Mar 17;13(585):. (PMID: 33731435)
Diabetes. 2013 Jul;62(7):2530-8. (PMID: 23423570)
Annu Rev Immunol. 2016 May 20;34:369-94. (PMID: 27168242)
Ann N Y Acad Sci. 2018 Jan;1411(1):153-165. (PMID: 29377202)
Sci Transl Med. 2019 May 15;11(492):. (PMID: 31092696)
Lancet Diabetes Endocrinol. 2018 Mar;6(3):186-196. (PMID: 29275068)
Pharmaceutics. 2022 Feb 21;14(2):. (PMID: 35214189)
J Extracell Vesicles. 2022 Dec;11(12):e12283. (PMID: 36519808)
Adv Drug Deliv Rev. 2022 Mar;182:114108. (PMID: 34990792)
Sci Transl Med. 2014 Dec 3;6(265):265sr6. (PMID: 25473038)
Nat Rev Mol Cell Biol. 2020 Jul;21(7):363-383. (PMID: 32231263)
Lancet. 2003 May 3;361(9368):1545-51. (PMID: 12737879)
JAMA. 2017 Oct 10;318(14):1387-1388. (PMID: 29049573)
Adv Funct Mater. 2020 Sep 10;30(37):. (PMID: 32952493)
Chem Soc Rev. 2021 Mar 21;50(6):3842-3888. (PMID: 33522550)
Cell. 2021 Jul 22;184(15):3852-3872. (PMID: 34297930)
Mol Nutr Food Res. 2018 Jan;62(2):. (PMID: 28849618)
Foot Ankle. 1981 Sep;2(2):64-122. (PMID: 7319435)
Lancet. 2005 Nov 12;366(9498):1736-43. (PMID: 16291068)
Pharmacol Res. 2022 Apr;178:106149. (PMID: 35240272)
Adv Sci (Weinh). 2024 May;11(18):e2307630. (PMID: 38441389)
Int J Mol Sci. 2021 Dec 24;23(1):. (PMID: 35008617)
Diabetes Metab Res Rev. 2012 Feb;28 Suppl 1:64-71. (PMID: 22271726)
Diabetes. 2016 Mar;65(3):633-46. (PMID: 26647385)
Immunity. 2021 May 11;54(5):903-915. (PMID: 33979587)
Cell Host Microbe. 2018 Nov 14;24(5):637-652.e8. (PMID: 30449315)
J Clin Invest. 2007 May;117(5):1219-22. (PMID: 17476353)
Exp Mol Med. 2022 Aug;54(8):1067-1075. (PMID: 35978054)
Cell Stem Cell. 2012 Jul 6;11(1):127-35. (PMID: 22770246)
Nucleic Acids Res. 2023 Jan 6;51(D1):D1257-D1262. (PMID: 36169237)
Nat Rev Mol Cell Biol. 2018 Apr;19(4):213-228. (PMID: 29339798)
Genome Res. 2003 Nov;13(11):2498-504. (PMID: 14597658)
Science. 2018 Jun 8;360(6393):1126-1129. (PMID: 29773668)
Diabetes Res Clin Pract. 2022 Jan;183:109119. (PMID: 34879977)
Sci Adv. 2021 Aug 27;7(35):. (PMID: 34452918)
Nat Nanotechnol. 2021 Jul;16(7):748-759. (PMID: 34211166)
Nat Rev Rheumatol. 2016 Apr;12(4):243-9. (PMID: 26729461)
Adv Drug Deliv Rev. 2021 Oct;177:113929. (PMID: 34403750)
Free Radic Biol Med. 2019 Jul;138:53-62. (PMID: 31035003)

81871735 National Natural Science Foundation of China; 82172371 National Natural Science Foundation of China; 82302639 National Natural Science Foundation of China; 2023M731555 China Postdoctoral Science Foundation; 2020J007 Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University; 2019B1515120074 Basic and Applied Basic Research Foundation of Guangdong Province; 2021YFA1300604 National Key R&D Program of China; 82025024 National Science Fund for Distinguished Young Scholars

Keywords: Nrf2/HO‐1 pathway; aerogels; cross‐kingdom regulations; diabetic wound healing; turmeric‐derived nanoparticles

Date Created: 20240305 Date Completed: 20240515 Latest Revision: 20240517

20240517

PMC11095230

10.1002/advs.202307630

38441389