Association between sun exposure habits and disease progression in multiple sclerosis.

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  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: England NLM ID: 9506311 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-1331 (Electronic) Linking ISSN: 13515101 NLM ISO Abbreviation: Eur J Neurol Subsets: MEDLINE
    • Publication Information:
      Publication: <2014- > : Oxford : Wiley
      Original Publication: Oxford ; New York : Rapid Communications, [1994-
    • Subject Terms:
      Disease Progression* ; Sunlight* ; Multiple Sclerosis*/epidemiology ; Registries* ; Quality of Life*; Humans ; Male ; Female ; Adult ; Middle Aged ; Case-Control Studies ; Sweden/epidemiology ; Habits ; Disability Evaluation
    • Abstract:
      Background and Purpose: Higher latitude has been associated with increased occurrence of multiple sclerosis (MS) and with more severe disease. The aim was to study the impact of sun exposure habits on MS disease progression and health-related quality of life.
      Methods: Patients from a population-based case-control study were categorized based on sun exposure habits at diagnosis and were followed up to 15 years post-diagnosis through the Swedish MS registry (n = 3314) with regard to changes in Expanded Disability Status Scale (EDSS). Linear mixed models were used to analyse long-term changes, while Cox regression models, with 95% confidence intervals, were used to investigate outcomes, including 24-week confirmed diasability worsening, EDSS3, EDSS4, and physical worsening as measured by the physical component of the Multiple Sclerosis Impact Scale 29.
      Results: Compared to average sun exposure (median value), low exposure to sunlight was associated with faster EDSS progression, increased risk of confirmed disability worsening (hazard ratio [HR] 1.48, 95% CI 1.21-1.81), increased risk of reaching EDSS 3 (HR 1.35, 95% CI 1.02-1.79), EDSS 4 (HR 1.47, 95% CI 1.01-2.20) and self-reported physical worsening (HR 1.27, 95% CI 1.00-1.62). Significant trends revealed a lower risk of unfavourable outcomes with increasing sun exposure.
      Conclusions: Very low levels of sun exposure are associated with worse disease progression and health-related quality of life in patients with MS.
      (© 2024 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
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    • Grant Information:
      201907930017 Chinese Scholarship Council; NEURO Sweden; Margaretha af Ugglas Foundation; Medicinska Forskningsrådet; FO2020-0077 Swedish Brain Foundation; FO2022-0123 Swedish Brain Foundation; 2015-00195 Forskningsrådet om Hälsa, Arbetsliv och Välfärd; 2019-00697 Forskningsrådet om Hälsa, Arbetsliv och Välfärd; 2016-02349 Vetenskapsrådet; 2017-00777 Vetenskapsrådet; 2020-01998 Vetenskapsrådet
    • Contributed Indexing:
      Keywords: Expanded Disability Status Scale; disability worsening; disease activity; life quality; multiple sclerosis; sun exposure
    • Publication Date:
      Date Created: 20240305 Date Completed: 20240508 Latest Revision: 20240727
    • Publication Date:
      20240727
    • Accession Number:
      PMC11235876
    • Accession Number:
      10.1111/ene.16269
    • Accession Number:
      38440929