Natural History of Type 2 Diabetes in Indians: Time to Progression.

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  • Additional Information
    • Source:
      Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
    • Publication Information:
      Publication: Alexandria Va : American Diabetes Association
      Original Publication: New York, American Diabetes Assn.
    • Subject Terms:
      Diabetes Mellitus, Type 2*/epidemiology ; Prediabetic State*/epidemiology ; Glucose Intolerance*/epidemiology; Humans ; Longitudinal Studies ; Blood Glucose
    • Abstract:
      Objective: To describe the natural history of diabetes in Indians.
      Research Design and Methods: Data are from participants older than 20 years in the Centre for Cardiometabolic Risk Reduction in South Asia longitudinal study. Glycemic states were defined per American Diabetes Association criteria. Markov models were used to estimate annual transition probabilities and sojourn time through states.
      Results: Among 2,714 diabetes-free participants, 641 had isolated impaired fasting glucose (iIFG), and 341 had impaired glucose tolerance (IGT). The annual transition to diabetes for those with IGT was 13.9% (95% CI 12.0, 15.9) versus 8.6% (7.3, 9.8) for iIFG. In the normoglycemia ↔ iIFG → diabetes model, mean sojourn time in normoglycemia was 40.3 (34.6, 48.2) years, and sojourn time in iIFG was 9.7 (8.4, 11.4) years. For the normoglycemia ↔ IGT → diabetes model, mean sojourn time in normoglycemia was 34.5 (29.5, 40.8) years, and sojourn time in IGT was 6.1 (5.3, 7.1) years.
      Conclusions: Individuals reside in normoglycemia for 35-40 years; however, progression from prediabetes to diabetes is rapid.
      (© 2024 by the American Diabetes Association.)
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    • Grant Information:
      P30 DK111024 United States DK NIDDK NIH HHS; 5U01HL138635 United States TW FIC NIH HHS; R01 HL125442 United States HL NHLBI NIH HHS; P01 HL154996 United States HL NHLBI NIH HHS; D43 TW009135 United States TW FIC NIH HHS; U01 HL138635 United States HL NHLBI NIH HHS; HHSN268200900026C United States HL NHLBI NIH HHS
    • Accession Number:
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20240301 Date Completed: 20240422 Latest Revision: 20240427
    • Publication Date:
      20240427
    • Accession Number:
      PMC11043225
    • Accession Number:
      10.2337/dc23-1514
    • Accession Number:
      38427346