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[Development and progress of the National Autopsy Network (NATON)].
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- Author(s): Windeck S;Windeck S; Allgoewer K; Allgoewer K; von Stillfried S; von Stillfried S; Triefenbach L; Triefenbach L; Nienaber U; Nienaber U; Bülow RD; Bülow RD; Röhrig R; Röhrig R; Ondruschka B; Ondruschka B; Boor P; Boor P
- Source:
Pathologie (Heidelberg, Germany) [Pathologie (Heidelb)] 2024 May; Vol. 45 (3), pp. 203-210. Date of Electronic Publication: 2024 Mar 01.- Publication Type:
English Abstract; Journal Article; Review- Language:
German - Source:
- Additional Information
- Transliterated Title: Entwicklung und Fortschritte des Nationalen Obduktionsnetzwerks (NATON).
- Corporate Authors:
- Source: Publisher: Springer Medizin Country of Publication: Germany NLM ID: 9918384887506676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-7196 (Electronic) Linking ISSN: 27317188 NLM ISO Abbreviation: Pathologie (Heidelb) Subsets: MEDLINE
- Publication Information: Original Publication: [Heidelberg, Germany] : Springer Medizin, [2022]-
- Subject Terms:
- Abstract: Background: Autopsies have long been considered the gold standard for quality assurance in medicine, yet their significance in basic research has been relatively overlooked. The COVID-19 pandemic underscored the potential of autopsies in understanding pathophysiology, therapy, and disease management. In response, the German Registry for COVID-19 Autopsies (DeRegCOVID) was established in April 2020, followed by the DEFEAT PANDEMIcs consortium (2020-2021), which evolved into the National Autopsy Network (NATON).
Deregcovid: DeRegCOVID collected and analyzed autopsy data from COVID-19 deceased in Germany over three years, serving as the largest national multicenter autopsy study. Results identified crucial factors in severe/fatal cases, such as pulmonary vascular thromboemboli and the intricate virus-immune interplay. DeRegCOVID served as a central hub for data analysis, research inquiries, and public communication, playing a vital role in informing policy changes and responding to health authorities.
Naton: Initiated by the Network University Medicine (NUM), NATON emerged as a sustainable infrastructure for autopsy-based research. NATON aims to provide a data and method platform, fostering collaboration across pathology, neuropathology, and legal medicine. Its structure supports a swift feedback loop between research, patient care, and pandemic management.
Conclusion: DeRegCOVID has significantly contributed to understanding COVID-19 pathophysiology, leading to the establishment of NATON. The National Autopsy Registry (NAREG), as its successor, embodies a modular and adaptable approach, aiming to enhance autopsy-based research collaboration nationally and, potentially, internationally.
(© 2024. The Author(s).) - References: Am J Obstet Gynecol. 2022 Jan;226(1):135-136. (PMID: 34228972)
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Angiogenesis. 2023 May;26(2):233-248. (PMID: 36371548)
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Nat Commun. 2020 Oct 8;11(1):5086. (PMID: 33033248)
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N Engl J Med. 2020 Jul 9;383(2):120-128. (PMID: 32437596) - Contributed Indexing: Keywords: Autopsy; COVID-19; Disease management; Germany; Registries
Local Abstract: [Publisher, German] HINTERGRUND: Obduktionen gelten seit langem als der Goldstandard für die Qualitätssicherung in der Medizin. Die COVID-19-Pandemie hat ihr Potenzial für das Verständnis der Pathophysiologie, Therapie und Krankheitsbewältigung wieder in den Fokus gerückt. Im April 2020 wurde das Deutsche Register für COVID-19-Obduktionen (DeRegCOVID) eingerichtet, gefolgt vom Konsortium DEFEAT PANDEMIcs (2020–2021), das sich zum Nationalen Obduktionsnetzwerk (NATON) entwickelte. [Publisher, German] DeRegCOVID sammelte und analysierte über 3 Jahre hinweg Obduktionsdaten von COVID-19-Verstorbenen in Deutschland und ist damit die größte nationale multizentrische Obduktionsstudie. Die Ergebnisse identifizierten entscheidende Faktoren für schwere/tödliche Fälle, wie z. B. pulmonale vaskuläre Thromboembolien, und das komplizierte Zusammenspiel von Virus und Immunsystem. DeRegCOVID diente als zentraler Hub für die Datenanalyse, Forschungsanfragen und öffentliche Kommunikation und spielte eine wichtige Rolle im Austausch mit Politik und öffentlichem Gesundheitswesen. [Publisher, German] NATON wurde vom Netzwerk Universitätsmedizin (NUM) initiiert und entwickelte sich zu einer nachhaltigen Infrastruktur für autopsiebasierte Forschung. Ziel ist die Bereitstellung einer Daten- und Methodenplattform, die die Zusammenarbeit zwischen Pathologie, Neuropathologie und Rechtsmedizin fördert. Die Struktur unterstützt eine rasche Rückkopplung zwischen Forschung, Patientenversorgung und Pandemiemanagement. [Publisher, German] DeRegCOVID hat wesentlich zum Verständnis der COVID-19-Pathophysiologie beigetragen. Durch seinen modularen Aufbau will das Nationale Obduktionsregister (NAREG) nun die Zusammenarbeit auf nationaler sowie internationaler Ebene weiter verbessern. - Publication Date: Date Created: 20240301 Date Completed: 20240425 Latest Revision: 20240524
- Publication Date: 20240525
- Accession Number: PMC11045591
- Accession Number: 10.1007/s00292-024-01307-8
- Accession Number: 38427066
- Transliterated Title:
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