Association of dietary live microbe intake with diabetic kidney disease in patients with type 2 diabetes mellitus in US adults: a cross-sectional study of NHANES 1999-2018.

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  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer Verlag
      Original Publication: Berlin : Springer International, c1991-
    • Subject Terms:
      Diabetes Mellitus, Type 2*/complications ; Diabetes Mellitus, Type 2*/epidemiology ; Diabetic Nephropathies*/epidemiology ; Diabetic Nephropathies*/etiology ; Nutrition Surveys*; Humans ; Female ; Male ; Cross-Sectional Studies ; Middle Aged ; Aged ; Adult ; Diet/statistics & numerical data ; United States/epidemiology ; Glomerular Filtration Rate
    • Abstract:
      Aims: Several studies have reported dietary microorganisms' beneficial effects on human health. We aimed to detect the potential association between dietary live microbe intake and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM) through a cross-sectional analysis of the National Health and Nutrition Examination Survey from 1999 to 2018.
      Methods: According to the Sanders classification system of dietary live microbes, the study participants were divided into three groups: low, medium, and high live microbe groups. In patients with T2DM, DKD was assessed by glomerular filtration rate (< 60 mL/min/1.73 m 2 using the Chronic Kidney Disease Epidemiology Collaboration algorithm), proteinuria (urinary albumin to creatinine ratio ≥ 30 mg/g), or both. Weighted univariate and multivariate logistic regression and subgroup analyses were conducted to investigate the independent association between dietary live microbe and DKD.
      Results: The study included 3836 participants, of whom 1467 (38.24%) had DKD for the diagnosis. Our study demonstrated that participants in the high dietary live microbe group were more likely to be older, female, non-Hispanic White, have higher education levels, have a lower prevalence of smoking, have a high poverty-income ratio, have higher energy intake, lower haemoglobin (HbA1c) and serum creatinine levels, and lower risk of progression. After adjustment for covariates, patients in the high dietary live microbe group had a low prevalence of DKD, whereas no significant association with DKD was found between the medium and low dietary live microbe groups. No statistically significant interaction was observed in all subgroup analyses except for HbA1c (p for interaction < 0.05).
      Conclusions: Our results indicate that high dietary live microbe intake was associated with a low DKD prevalence.
      (© 2024. The Author(s).)
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    • Grant Information:
      XLYC1902080 Science and Technology Innovative Leading Talent Fund of Xingliao Talents Program (Liaoning Specially-invited Professors); No. 22PJD061 the Shanghai Pujiang Talent Plan; No. 82070754 Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: Cross-sectional study; Diabetic kidney disease; Dietary live microbe; NHANES; Type 2 diabetes mellitus
    • Publication Date:
      Date Created: 20240224 Date Completed: 20240517 Latest Revision: 20240520
    • Publication Date:
      20240520
    • Accession Number:
      PMC11101549
    • Accession Number:
      10.1007/s00592-023-02231-8
    • Accession Number:
      38400938