Electrospun membranes of diselenide-containing poly(ester urethane)urea for in situ catalytic generation of nitric oxide.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Gao Y;Gao Y; Bai S; Bai S; Zhu K; Zhu K; Yuan X; Yuan X
  • Source:
    Journal of biomaterials science. Polymer edition [J Biomater Sci Polym Ed] 2024 Jun; Vol. 35 (8), pp. 1157-1176. Date of Electronic Publication: 2024 Feb 22.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Taylor and Francis Country of Publication: England NLM ID: 9007393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5624 (Electronic) Linking ISSN: 09205063 NLM ISO Abbreviation: J Biomater Sci Polym Ed Subsets: MEDLINE
    • Publication Information:
      Publication: 2012- : Abingdon, Oxon : Taylor and Francis
      Original Publication: Utrecht, The Netherlands : VSP, c1989-
    • Subject Terms:
      Nitric Oxide*/chemistry ; Nitric Oxide*/metabolism ; Polyurethanes*/chemistry ; Polyesters*/chemistry ; Biocompatible Materials*/chemistry ; Biocompatible Materials*/pharmacology; Humans ; Catalysis ; Human Umbilical Vein Endothelial Cells ; Hemolysis/drug effects ; Membranes, Artificial ; Cell Proliferation/drug effects ; Adsorption
    • Abstract:
      Nitric oxide (NO) plays an important role as a signalling molecule in the biological system. Organoselenium-coated or grafted biomaterials have the potential to achieve controlled NO release as they can catalyse decomposition of endogenous S -nitrosothiols to NO. However, such biomaterials are often challenged by the loss of the catalytic sites, which can affect the stability in tissue repair applications. In this work, we prepare a diselenide-containing poly(ester urethane)urea (SePEUU) polymer with Se-Se in the backbone, which is further electrospun into fibrous membranes by blending with poly(ester urethane)urea (PEUU) without diselenide bonds. The presence of catalytic sites in the main chain demonstrates stable and long-lasting NO catalytic activity, while the porous structure of the fibrous membranes ensures uniform distribution of the catalytic sites and better contact with the donor-containing solution. PEUU/SePEUU50 in 50/50 mass ratio has a physiologically adapted rate of NO release, with a sustained generation of NO after exposure to PBS at 37 °C for 30 d. PEUU/SePEUU50 has a low hemolysis and protein adsorption, with mechanical properties in the wet state matching those of natural vascular tissues. It can promote the adhesion and proliferation of human umbilical vein endothelial cells in vitro and control the proliferation of vascular smooth muscle cells in the presence of NO generation. This study exhibits the electrospun fibrous membranes have potential for utilizing as hemocompatible biomaterials for regeneration of blood-contacting tissues.
    • Contributed Indexing:
      Keywords: Electrospun membranes; diselenide-containing polymer; mechanical properties; nitric oxide; poly(ester urethane) urea
    • Accession Number:
      0 (poly(ester urethane)urea)
    • Publication Date:
      Date Created: 20240222 Date Completed: 20240522 Latest Revision: 20240613
    • Publication Date:
      20240613
    • Accession Number:
      10.1080/09205063.2024.2319416
    • Accession Number:
      38386369