Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive-compulsive disorder.

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  • Additional Information
    • Source:
      Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE
    • Publication Information:
      Original Publication: Hoboken, NJ : John Wiley & Sons
    • Subject Terms:
      Dorsolateral Prefrontal Cortex* ; Obsessive-Compulsive Disorder*; Humans ; Magnetic Resonance Imaging/methods ; Gyrus Cinguli/diagnostic imaging ; Brain ; Prefrontal Cortex/diagnostic imaging ; Brain Mapping/methods
    • Abstract:
      Background: Neuroimaging studies have revealed the role of the right dorsolateral prefrontal cortex (DLPFC) in the neurobiological mechanism of obsessive-compulsive disorder (OCD). However, only a few studies have examined the functional connectivity (FC) pattern of the right DLPFC at rest in OCD.
      Objective: The aim of this research is to examine the FC patterns of the right DLPFC at rest in OCD.
      Methods: Twenty-eight medication-free patients with OCD and 20 healthy controls underwent resting-state functional magnetic resonance imaging. Seed-based FC and support vector machine (SVM) were used to analyze the imaging data.
      Results: The patients with OCD showed reduced FC values in the right middle temporal gyrus (MTG), right superior temporal gyrus, right ventral anterior cingulate cortex (vACC), and left Crus II. No brain regions showed a remarkable difference in FC values in patients with OCD after 8 weeks of medication treatment. The reduced right DLPFC-right MTG and right DLPFC-right vACC connectivities were correlated with the clinical symptoms of OCD. SVM results showed that reduced right DLPFC-right MTG connectivity at rest could predict the therapeutic response to OCD medication.
      Conclusions: The findings highlight the important role of the right DLPFC in the pathophysiological mechanism of OCD.
      (© 2024 The Authors. Brain and Behavior published by Wiley Periodicals LLC.)
    • References:
      Neurosci Biobehav Rev. 2008;32(3):525-49. (PMID: 18061263)
      J Affect Disord. 2019 Dec 1;259:47-55. (PMID: 31437701)
      J Affect Disord. 2017 Jan 01;207:203-211. (PMID: 27723545)
      J Psychiatry Neurosci. 2014 Sep;39(5):304-11. (PMID: 24866415)
      Neurosci Lett. 2017 Feb 15;640:99-104. (PMID: 28104431)
      Acta Neuropsychiatr. 2017 Jun;29(3):164-169. (PMID: 27748207)
      Psychiatry Clin Neurosci. 2016 Oct;70(10):448-456. (PMID: 27377579)
      Front Psychiatry. 2019 Jun 28;10:452. (PMID: 31316408)
      J Affect Disord. 2015 Dec 1;188:243-51. (PMID: 26378734)
      Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10046-51. (PMID: 16788060)
      Science. 2013 Jun 7;340(6137):1234-9. (PMID: 23744948)
      Neurosci Biobehav Rev. 2017 Jul;78:91-103. (PMID: 28442404)
      J Affect Disord. 2017 Jun;215:187-196. (PMID: 28340445)
      BMC Psychiatry. 2019 Jul 5;19(1):210. (PMID: 31277632)
      Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:1144-1147. (PMID: 30440592)
      Psychiatry Res Neuroimaging. 2019 Jan 30;283:24-33. (PMID: 30500474)
      J Psychiatr Res. 2012 Dec;46(12):1635-42. (PMID: 23040160)
      Brain Cogn. 2016 Feb;102:46-54. (PMID: 26720411)
      Biol Psychiatry. 2019 May 1;85(9):735-743. (PMID: 30777287)
      JAMA Psychiatry. 2016 Aug 1;73(8):815-825. (PMID: 27276220)
      Front Psychiatry. 2020 Mar 03;11:98. (PMID: 32194450)
      Trends Cogn Sci. 2000 Jun;4(6):215-222. (PMID: 10827444)
      Asian J Psychiatr. 2012 Dec;5(4):290-6. (PMID: 23174435)
      PLoS One. 2013 Jun 27;8(6):e67262. (PMID: 23826251)
      Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jul 13;93:77-83. (PMID: 30905622)
      Mol Psychiatry. 2010 Jan;15(1):53-63. (PMID: 18725912)
      J Clin Psychiatry. 2001 Dec;62(12):981-4. (PMID: 11780880)
      Ann Thorac Surg. 1998 May;65(5):1320-5. (PMID: 9594860)
      Psychol Med. 2019 May;49(7):1156-1165. (PMID: 30058519)
    • Grant Information:
      LHGJ20220636 Henan Joint Construction Project of medical science and technology; 182300410317 Henan Natural Science Foundation Grant; 2022-xyefykfkt-002 Open Project of Psychiatry and Neuroscience Discipline of Second Affiliated Hospital of Xinxiang Medical University; QMSI2017B-08 The Project of Qiqihar Academy of Medical Sciences, China; LH2019H064 Heilongjiang Natural Science Foundation of China; ZDSYS2022D02 Open Program of Henan Key Laboratory of Biological Psychiatry; 232102310085 Henan Key research and development and promotion projects
    • Contributed Indexing:
      Keywords: functional connectivity; functional magnetic resonance imaging; obsessive-compulsive disorder; resting-state; right dorsolateral prefrontal cortex
    • Publication Date:
      Date Created: 20240220 Date Completed: 20240221 Latest Revision: 20240307
    • Publication Date:
      20240307
    • Accession Number:
      PMC10784187
    • Accession Number:
      10.1002/brb3.3333
    • Accession Number:
      38376021